Inverse association between height increase and <scp>LDL</scp> cholesterol during puberty: A 3‐year follow‐up study of the <scp>F</scp>ukuroi <scp>C</scp>ity

Fujita, Yuki; Kouda, Katsuyasu; Nakamura, Harunobu; Iki, Masayuki

doi:10.1002/ajhb.22784

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…The Bogalusa Heart Study reported that changes in height for five years in boys were inversely correlated with TC, LDL-C, and HDL-C levels 12 (9). This negative correlation between the LDL-C concentration and growth rate in both boys and girls was also supported by the findings of large-scale prospective study conducted in Japan 14 . Finally, a recent study of 6,300 adolescents conducted by the West Virginia Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) project reported that the risk of hyper-LDL-cholesterolemia increases significantly in the first (shortest) quartile stature compared with that in the fourth (tallest) quartile stature (OR = 1.3~3) 15 .…”

Section: Discussionsupporting

confidence: 67%

Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults

Song

Kim

et al. 2019

Sci Rep

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Adults with short stature have been previously reported to have increased risk of cardiovascular events and hyper-LDL-cholesterolemia. We aimed to assess the association between height and lipid profiles among Korean adolescents and adults. We analyzed data from the Korea National Health and Nutrition Examination Survey from 2007 to 2015, from 37,889 individuals (aged 12–59 years). In adolescents, total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) levels had profound associations with height in both boys and girls, while high density lipoprotein-cholesterol (HDL-C) levels had an inverse association with height only in boys. Height was inversely associated with TC, triglycerides (TG), and LDL-C concentrations in men and women and positively correlated with HDL-C concentration in women. In boys, the odds ratios (ORs) for hypercholesterolemia, hypertriglyceridemia, hyper-LDL-cholesterolemia were higher for shorter subjects (ORs = 2.38~7.01), while only the OR of hyper-LDL-cholesterolemia was significantly higher in girls with short stature (OR = 3.12). In adults, the ORs for hypercholesterolemia, hypo-HDL-cholesterolemia, and hyper-LDL-cholesterolemia were significantly higher in short subjects than in tall subjects after controlling for covariates (ORs = 1.50~2.61). Also, short men showed significantly higher ORs for hypertriglyceridemia (OR = 1.85) than tall men. Short stature was significantly associated with adverse lipid profiles in both adolescents and adults.

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Section: Discussionsupporting

confidence: 67%

Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults

Song

Kim

et al. 2019

Sci Rep

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“…3,4 Accordingly, search has begun for a simple indicator to access obesity-related metabolic risks that should be practical and cost-effective to measure, more sensitive than BMI and WC, and with a universal cut-point for both sexes and subjects of different ethnic groups. Some have suggested the WC/height (WC/H) ratio as an indicator of obesity-related health risks, hypothesizing that since shorter subjects tend to have a higher risk of developing abnormalities (metabolic syndrome and related diseases 9,10 ), height should be taken into account when WC is used as a putative obesity marker. 11 Some studies among adults have demonstrated that the WC/H index is useful as a screening tool for obesity and related metabolic disorders, 6,12,13 and a cut-point of 0.5 seems to be a suitable boundary value to identify subjects at risk of metabolic disorders, independent of sex and ethnicity.…”

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confidence: 99%

Identifying the best body‐weight‐status index associated with metabolic risk in youth

Gomes

Nevill

Katzmarzyk

et al. 2018

Scandinavian Med Sci Sports

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This study investigated the association of six different anthropometric markers with metabolic syndrome to find the most suited to predict children at risk. Sample comprises 1324 Portuguese youth (701 girls, 623 boys), aged 10-17 years. Six anthropometric markers were included: body mass index (BMI), BMI z-score, tri-ponderal index (TPI), waist circumference (WC), WC/height ratio (WC/H), and WC/H adjusted ratio (WC/H ). A standardized metabolic risk score (zMR) was computed by summing of standardized values for fasting glucose, triglycerides, high-density lipoprotein cholesterol, and mean arterial blood pressure. The associations between zMR and anthropometric markers were assessed using univariate and multivariate analyses. Receiver operating characteristic (ROC) curve analysis was used to identify the optimal values that best predict metabolic risk of each anthropometric marker. Among the studied predictors, BMI z-score, followed by BMI and WC, was most highly associated with zMR, while WC/H was the weakest predictor. ROC analyses showed significant AUCs for all markers, yet the discrimination was poor (AUCs from 0.60 to 0.68), with sensitivity ranging from 45.5% to 67.5% and specificity from 72.6% to 81.9%. The optimal cut-off values to predict metabolic risk were 1.62, 23.1 kg/m , 71.0 cm, 18.0 kg/m , 0.47, and 0.50, for BMI z-score, BMI, WC, TPI, WC/H, and WC/H , respectively. BMI z-score, followed by BMI and WC, were the most relevant anthropometric markers to predict metabolic risk in youth, while WC/H was the worst predictor. Results suggest that anthropometric markers should continue to be used as clinical tools to identify youth at risk.

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“…The odds ratio of dyslipidemia (LDL > 140 mg/dl or triglycerides 150 mg/dl) fell from the first (shortest) to fourth (tallest) quartile in those under 25 kg/m 2 , but was nonsignificant for those 25 kg/m 2 . Fujita et al measured lipids in 2,515 students in public schools in Fukeroi, Japan, from 2008 to 2010 and then again in the eighth grade with follow-up in 2,225 students (9). Lipid levels decreased in association with largest increased height over 3 years, but this was attenuated in the group with a larger weight increment.…”

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confidence: 99%

LDL cholesterol level in fifth-grade schoolchildren associates with stature

Pyles

Lilly

Mullett

et al. 2017

Journal of Lipid Research

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Short stature is associated with increased LDL-cholesterol levels and coronary artery disease in adults. We investigated the relationship of stature to LDL levels in children in the West Virginia Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) Project to determine whether the genetically determined inverse relationship observed in adults would be evident in fifth graders. A cross-sectional survey of schoolchildren was assessed for cardiovascular risk factors. Data collected at school screenings over 18 years in WV schools were analyzed for 63,152 fifth-graders to determine relationship of LDL to stature with consideration of age, gender, and BMI. The first (shortest) quartile showed an LDL level of 93.6 mg/dl compared with an LDL level of 89.7 mg/dl for the fourth (tallest) quartile. Each incremental increase of 1 SD of height lowered LDL by 0.049 mg/dl ( < 0.0001). Multivariate analysis showed LDL to vary inversely as a function of the first (lowest) quartile of height after controlling for gender, median age, BMI percentile for age and gender, and year of screening. The odds ratio for LDL ≥ 130 mg/dl for shortest versus tallest quartile is 1.266 (95% CL 1.162-1.380). The odds ratio for LDL ≥ 160 mg/dl is 1.456 (95% CL 1.163-1.822). The relationship between short stature and LDL, noted in adults, is confirmed in childhood.

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Inverse association between height increase and LDL cholesterol during puberty: A 3‐year follow‐up study of the Fukuroi City

Abstract: Serum LDL-C decreased with increasing height, independent of increases in weight. The association between LDL-C and height is stronger than that between LDL-C and weight. Am. J. Hum. Biol. 28:330-334, 2016. © 2015 Wiley Periodicals, Inc.

Cited by 5 publications

References 18 publications

Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults

Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults

Identifying the best body‐weight‐status index associated with metabolic risk in youth

LDL cholesterol level in fifth-grade schoolchildren associates with stature

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