Inverse association of des-acyl ghrelin with worksite blood pressure in overweight/obese male workers

Narisada, Akihiko; Hasegawa, Tomomi; Nakahigashi, Maki; T, Hirobe; Ikemoto, Tatsunori; Ushida, Takahiro; Kobayashi, Fumio

doi:10.1007/s12199-015-0454-6

Cited by 4 publications

(3 citation statements)

References 52 publications

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“…In the work context (productivity and cost), obesity is also associated with negative consequences among workers, including more frequent absenteeism, sick leave, workplace injury, and greater healthcare costs 43 44. Additionally, obesity strengthens the effect of work-related psychological stress on workplace blood pressure and autonomic nervous dysfunction, which can induce CVD and sudden death, including karōshi (death from overwork) 45–47. To prevent these diseases and harmful results, male white-collar workers with high procrastination levels should be monitored more carefully for undesirable adult weight gain (ie, weight gain over 3 kg in 1 year).…”

Section: Discussionmentioning

confidence: 99%

Association between procrastination, white-collar work and obesity in Japanese male workers: a cross-sectional study

Narisada

Suzuki

2019

BMJ Open

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ObjectiveTo investigate the associations among procrastination (time inconsistency), work environment and obesity-related factors in Japanese male workers.DesignCross-sectional study.SettingData were collected at two work sites of Japanese electronics manufacturing company in 2015.Participants795 full-time male workers in a Japanese electric company, aged 35–64 years, who underwent health checkups in 2015.Main outcome measuresBody mass index (BMI), adult weight change, obesity (BMI ≥25 kg/m2), adult weight gain over 10 kg (AWG10) and metabolic syndrome (MetS). Multivariable linear and logistic regression analyses were performed to assess the associations of procrastination assessed by using a one-item questionnaire and white-collar and blue-collar work with obesity-related factors.ResultsWhite-collar workers with high procrastination levels showed positive associations with BMI (B: 0.75, 95% CI 0.06 to 1.44) and adult weight change (B: 1.77, 95% CI 0.26 to 3.29), and had increased odds of AWG10 (OR: 1.85, 95% CI 1.04 to 3.29) and MetS (OR: 2.29 95% CI 1.18 to 4.44) after adjustment for age, education, work-related factors and lifestyle factors. However, such positive associations were not observed among blue-collar workers.ConclusionsProcrastination and white-collar work might have a joint effect on weight gain during adulthood and consequential obesity.

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Section: Discussionmentioning

confidence: 99%

Association between procrastination, white-collar work and obesity in Japanese male workers: a cross-sectional study

Narisada

Suzuki

2019

BMJ Open

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“…Грелиновая сигнальная систе-ма включает в себя грелиновые рецепторы (GHSRgrowth hormone secretagogue receptor) и две формы грелиновых пептидов [8,10]. Отличительной осо-бенностью первой из них, так называемой ацилиро-ванной формы, является наличие боковой алкиль-ной (ацильной) цепи, чаще всего из 8 членов.…”

Section: Abstract unclassified

“…Воз-можное предположение о неэффективности приме-няемых доз препаратов и способа введения мало-вероятно, так как интраназальное введение грелина и других нейропептидных препаратов, в том числе в указанных дозах, хорошо зарекомендовало себя в эксперименте и клинике [2,10].…”

Section: обсуждение полученных результатовunclassified

Effects of ghrelin agonist and antagonist on endogenous desacyl-ghrelin content in the brain limbical structures under psychoemotional stress in rats

Khokhlov

Платонович²,

Tsikunov

et al. 2017

Rev Clin Pharm Drug Ther

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Background. During last years it has been shown the ghrelin signaling system not only regulates energy balance and food intake. It also takes part in reinforcement mechanisms and addiction formation. So the ghrelin system may be considered as possible molecular target to study addiction treatment and post-stressor pharmacological modulation. The aim of this work was to study the effects of ghrelin agonist and antagonist administration on des-acyl ghrelin (DAG) content in the brain structures under stress exposure in Wistar rats. Methods. The acute psychoemotional stress was realized by means of exposure of experimental rats to predator, a tiger python. Ghrelin or ghrelin antagonist D-Lys3-GHRP-6 (Tocris, UK) 10 µg in 20 µl administered intranasally for 7 days after stress exposure. Then brain structures were obtained, homogenized with cryogenic system “Cryomill 200” (Retsch, Germany) and investigated with high-sensitive ELISA (SP-BIO, France). Results. DAG have been detected in every brain structures studied. That are amygdala, hippocampus and hypothalamus. In control group of animals the DAG concentration in hypothalamus was 3-fold more comparning to hippocampus and 2-fold more conparning to amygdala content. The acute stress have dramatically 8-12-fold decrease of DAG concentrations in every brain structures studied. The pharmacological actions on GHSR receptor by ghrelin agonist and antagonist have not affect significant changes in DAG concentrations in every brain structures. Conclusions. The different concentrations of DAG in brain structures in control gtoup supports the view about ghrelin releasing neurons in the hypothalamus. Intranasal administration of ghrelin agonist and antagonist changes the levels of DAG in the hippocampus and the hypothalamus but not in the amygdala nucleus. Our data confirm the opinion about ghrelin-releasing neurons in hypothalamus. The experiments showed the acute stress had caused great depression of ghrelin system in various brain structures. The response of ghrelin system to acute stress occur possibly besides GHSR receptor pathway. The last have been suggested by absence of significant response to ghrelin agonist and antagonist administration.

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Impact of shift work on blood pressure among emergency medical services clinicians and related shift workers: A systematic review and meta-analysis

et al. 2020

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Inverse association of des-acyl ghrelin with worksite blood pressure in overweight/obese male workers

Abstract: Des-acyl ghrelin was inversely associated with Worksite BP, suggesting a unique beneficial effect of des-acyl ghrelin on Worksite BP in overweight/obese male day-shift workers.

Cited by 4 publications

References 52 publications

Association between procrastination, white-collar work and obesity in Japanese male workers: a cross-sectional study

Association between procrastination, white-collar work and obesity in Japanese male workers: a cross-sectional study

Effects of ghrelin agonist and antagonist on endogenous desacyl-ghrelin content in the brain limbical structures under psychoemotional stress in rats

Impact of shift work on blood pressure among emergency medical services clinicians and related shift workers: A systematic review and meta-analysis

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