Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population

Rattan, Puru; Penrice, Daniel D.; Ahn, Joseph; Ferrer, Alejandro; Patnaik, Mrinal M.; Shah, Vijay H.; Kamath, Patrick S.; Mangaonkar, Abhishek A.; Simonetto, Douglas A.

doi:10.1002/hep4.1803

Cited by 177 publications

(96 citation statements)

References 39 publications

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“…Heavy current drinkers were defined as ≥3 drinks per day for women and ≥4 drinks per day for men, with five or more binge drinking days per month; moderate drinkers were defined as ≥2 drinks per day for women and ≥3 drinks per day for men, with ≥2 binge drinking days per month. Light drinkers: did not meet the above criteria ( 11 , 12 ). In the US, PIR is defined as the ratio between a household's self-reported income and the poverty line.…”

Section: Methodsmentioning

confidence: 99%

The association of healthy eating index with periodontitis in NHANES 2013–2014

Wen

et al. 2022

Front. Nutr.

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BackgroundPeriodontal disease is very common worldwide and is one of the main causes of tooth loss in adults. Periodontal disease is characterized by chronic inflammation that can destroy adjacent alveolar bone and lead to a loss of periodontal ligaments. Although previous studies have found that a daily diet can influence the development of periodontal disease (e.g., a diet low in carbohydrates and rich in vitamins C and D and fiber can have a protective effect). Periodontal disease may present as gingivitis or periodontitis. However, studies on the role of healthy eating index in periodontitis are lacking. The purpose of this study was to assess the association between healthy eating index and periodontitis.MethodsWe analyzed data collected from participants in the National Health and Nutrition Examination Survey (NHANES), a nationally representative survey conducted in 2-year cycles from 2013 to 2014. As part of our analysis, we developed multivariate logistic regression models to examine the independent association between the healthy eating index and periodontitis. We evaluated the significance of association using odds ratios (OR) with 95% confidence intervals (95%CI).ResultsIndividuals with a lower total healthy eating index had a higher prevalence of periodontitis. Adjusted multivariate regression models showed that a higher healthy diet index was associated with a lower prevalence of periodontitis (OR = 0.69, 95% CI: 0.55–0.86, P < 0.05).ConclusionThe results of the study showed that dietary structure was associated with the prevalence of periodontitis. Patients with a higher healthy eating index had a lower prevalence of periodontitis. These findings will need to be confirmed by longitudinal, prospective studies in the future.

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Section: Methodsmentioning

confidence: 99%

The association of healthy eating index with periodontitis in NHANES 2013–2014

Wen

et al. 2022

Front. Nutr.

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“…Smoking more than 100 cigarettes in life and smoke not at all now were defined as former; the definition of now was smoking more than 100 cigarettes in life and smoking some days or every day (from the questionnaire in the database: smoked at least 100 cigarettes in life). The drink was divided into no, mild, moderate, and heavy as follows: heavy alcohol user: ≥3 drink times/day for women or ≥4 drink times/day for men or binge drinking on ≥5 days/month; moderate alcohol user: ≥2 drink times/day for women or ≥3 drink times/day for men or binge drinking ≥2 days/month; mild alcohol user: none of the above but drinking currently; and no was defined as never drinking ( 20 ).…”

Section: Methodsmentioning

confidence: 99%

Association between osteoporosis or osteopenia and taking antiplatelet agents in general US population of NHANES

Wang

Zhu

et al. 2022

Front. Endocrinol.

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BackgroundOsteoporosis (OP) and osteopenia are common bone disorders in old age, and lots of patients suffering from OP or osteopenia need to take antiplatelet agents to treat basic diseases. However, clinical data on the link between osteopenia or OP and antiplatelet agents are limited.MethodsData in this study were collected and screened from the NHANES from 2013 to 2014 and 2017 to 2018. The variables were extracted from interviews and compared between OP or osteopenia participants and normal. The relationship between OP or osteopenia and taking antiplatelet drugs was analyzed by weighted multivariate logistic regressionResultsAfter excluding individuals who were not eligible and had invalid data, we finally identified 894 participants for inclusion in the study. We found a negative association between OP or osteopenia and taking antiplatelet agents (OR = 0.53; 95% CI, 0.33–0.84; p < 0.05). These results did not change on multiple imputations (OR = 0.32, 95% CI, 0.19–0.56; p <0.01). In the subgroup analyses, the associations were more significant in women (OR = 0.18, 95% CI, 0.05–0.62; p <0.05).ConclusionThis study demonstrated that the association between OP or osteopenia and taking antiplatelet agents was significant. Therefore, it is necessary to confirm the result by extending further research.

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“…They found that men have shorter telomere lengths as compared to females. They also hypothesized that women have lower telomere attrition rates which could explain the lower mortality rates [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Gender differences in esophageal variceal bleeding in the United States

et al. 2022

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Background and Aims Esophageal variceal bleeding is a common reason for hospitalization in patients with cirrhosis. The main objective of this study was to analyze the effects of gender differences on outcomes in hospitalizations related to Esophageal variceal bleeding in the United States. Methods A retrospective observational cohort study was performed using the National Inpatient Sample (NIS) database for all hospitalizations with a discharge diagnosis of esophageal varices with hemorrhage from 2016 to 2019. The primary outcome was in-hospital mortality, while secondary outcomes included rate of early endoscopy (defined as less than 1 day), AKI, blood transfusion, sepsis, ICU admission and TIPS (Transjugular Intrahepatic Portosystemic Shunt). We also compared the length of stay and total hospitalization charges. Results We identified a total of 166,760 patients with variceal bleeding of which 32.7% were females. In-hospital mortality was higher in males, 9.91%, compared to females, 8.31% (adjusted odds ratio (aOR): 0.88, p-value=.008, when adjusted for confounding factors). The odds of undergoing an EGD, length of stay, or total hospitalization charges did not differ between the two groups. Compared to men, women had lower odds of receiving TIPS (aOR = 0.83, p-value=.002). Conclusion Women hospitalised with esophageal variceal bleeding are at a lower risk of death compared to males. Further research is needed to elucidate the factors associated with this lower risk.

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Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population

Cited by 177 publications

References 39 publications

The association of healthy eating index with periodontitis in NHANES 2013–2014

The association of healthy eating index with periodontitis in NHANES 2013–2014

Association between osteoporosis or osteopenia and taking antiplatelet agents in general US population of NHANES

Gender differences in esophageal variceal bleeding in the United States

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