Inverse Automated Treatment Planning with and without Individual Optimization in Interstitial Permanent Prostate Brachytherapy with High- and Low-Activity 125I

Abstract

Concerning the prostate dose coverage, high-activity seeds are superior in the IATP. After manual adjustment, the dose values for the prostate and the organs at risk are similar. Considering a supposedly decreased toxicity and a shorter implantation time for a lower number of seeds, we recommend high-activity seeds for experienced teams.

Transperineal Permanent Seed Implantation of “Low-Risk” Prostate Cancer

“…Implant quality was defined using the dose-volume histograms for the target volume prostate and the organs at risk (urethra, rectum) [27,32]. During the implantation, the position of the needle was controlled by ultrasound and fluoroscopy before implanting the seeds.…”

Changes of Dose Delivery Distribution within the First Month after Permanent Interstitial Brachytherapy for Prostate Cancer

“…Permanent interstitial brachytherapy with 125 I or 103 Pd seed implants is a common treatment for early-stage prostate cancer [7,10,11,16]. Computed tomography-(CT-)based dosimetry is currently recommended as the standard for postimplant dosimetry [1,8,12,13].…”

Response of Rat Prostate and Lung Tumors to Ionizing Radiation Combined with the Angiogenesis Inhibitor AMCA

“…Therefore, the purpose of the study is to determine whether radiation combined with AMCA as angiogenesis inhibitor will result in a better tumor response than with radiation alone [15,34,37,39].…”