Inverse Correlation Between Bone Mineral Density and Systemic Immune Inflammation Index in Postmenopausal Turkish Women

Abstract

Aim: In this study, the correlation between the change in bone mineral density (BMD) and the numerical value of the systemic immune inflammation index (SII) in postmenopausal Turkish women was investigated. Material and methods: The study comprised patients who had undergone menopause for at least one year and whose blood samples were examined by dual-energy X-ray absorptiometry (DEXA) on the same day. A retrospective evaluation of 527 postmenopausal women was performed. Age, body mass index (BMI), BMD, t score, neutrophil-lymphocyte-platelet-monocyte counts, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and SII (platelet count x neutrophil count/lymphocyte count) values were calculated and recorded. Results: When the data were analyzed with the Statistical Package for the Social Sciences (SPSS; IBM SPSS Statistics for Windows, version 26.0. Armonk, NY: IBM Corp.), neutrophil (p<0.001), lymphocyte (p=0.004), monocytes (p=0.002), platelet distribution width (PDW) (p=0.02), procalcitonin (PCT) (p=0.04), erythrocyte sedimentation rate (ESR) (p=0.001), C-reactive protein (CRP) (p=0.001), NLR (p=0.001), PLR (p=0.004), MLR (p=0.003), and SII (p=0.001) values were found to be higher in the postmenopausal osteoporosis (PMO) group than in the normal and osteopenia groups (p<0.05). When the platelet (p=0.15), mean platelet volume (MPV) (p=0.07), and 25-OH vitamin-D (p=0.15) values were compared, no correlation was found between the groups (normal, osteopenia, and PMO) (p>0.05). Conclusion: This study revealed that NLR, PLR, MLR, and SII values were inversely correlated with the change in BMD in postmenopausal Turkish women. These biomarkers, which are obtained from a simple, affordable, and accessible routine blood examination, may play an effective role in the early diagnosis and prevention of PMO in the future.

Correlation study: Bone density and circulating inflammatory markers in postmenopausal patients

“…However, due to its high cost and limited accessibility, its capability for early screening of PMOP remains inadequate 14 consequently, numerous scholars are endeavoring to identify more convenient and cost‐effective approaches for preliminary screening and diagnosis of PMOP. 12 , 15 , 16 , 17 While most studies focus on novel diagnostic technologies or targets, this study explores the early screening value of PMOP through the analysis of classic and readily accessible indicators obtained from routine blood tests.…”

Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic

“…Inflammatory activation, assessed using peripheral blood indexes based on counts of monocytes, neutrophils, lymphocytes, and platelets, has been considered as predictive in oncology [19,20], transplantology [21], and metabolic disorders [22,23]. Recent publications have shown relationship between NLR and risk of admission to the intensive care units among patients with COVID-19 [24].…”