Inverse correlation between coronary blood flow velocity and sICAM-1 level observed in ischemic heart disease patients

Bencze, J.; Kiss, Róbert Gábor; Tóth-Zsámboki, Emese; Vargová, Katarína; Kerecsen, Gábor; Korda, András; Molnár, Ferenc; Préda, István

doi:10.1016/j.atherosclerosis.2005.10.011

Cited by 9 publications

(5 citation statements)

References 28 publications

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“…Individuals with high BP show elevated levels of circulating soluble ICAM-1, and elevation of its circulating soluble form reflects increased expression on the endothelium, implying endothelial activation (20). Elevated levels of soluble intracellular adhesion molecule 1 (sICAM-1) have been consistently shown in cardiovascular diseases (9,10,(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

The Association of Social Status and Blood Pressure With Markers of Vascular Inflammation

Hong

Nelesen

Krohn

et al. 2006

Psychosomatic Medicine

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Section: Introductionmentioning

confidence: 99%

The Association of Social Status and Blood Pressure With Markers of Vascular Inflammation

Hong

Nelesen

Krohn

et al. 2006

Psychosomatic Medicine

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“…These researchers noticed the effect of body mass loss on the changes in expression of these genes. The next statistically significant difference stressing the role played by adhesion molecules in atherosclerotic processes was observed in persons with burdening family history [11]. The ICAM-2 molecule expression investigated by us also revealed statistically significant differences depending on burdening family history.…”

Section: Discussionmentioning

confidence: 89%

“…The most frequently investigated factors have been aortal hypertension, tobacco smoking, diabetes and obesity [11–13]. The study of Jin et al .…”

Section: Discussionmentioning

confidence: 99%

Expression analysis of intercellular adhesion molecule-2 (ICAM-2) in the context of classical cardiovascular risk factors in acute coronary syndrome patients

Głogowska-Ligus

Dąbek

Zych-Twardowska

et al. 2013

aoms

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IntroductionCardiopulmonary diseases are the most common cause of hospitalization and death. Often the basic problem is endothelial dysfunction leading to elevated expression of adhesion proteins as well as increased adhesion and aggregation of blood cells. The goal of the study was to assess expression level of intercellular adhesive molecule-2 (ICAM-2) in patients with acute coronary syndrome (ACS).Material and methodsThe obtained data were analysed in the context of the occurrence of classical cardiovascular risk factors. The two studied groups consisted of 60 ACS patients and 20 healthy individuals who both were qualified based on electrocardiography (ECG), transthoracic echocardiography and biochemical tests. The ACS patients additionally had coronary angiography performed. The number of ICAM-2 gene mRNA molecules was evaluated on the basis of QRT-PCR reaction kinetics. To compare the results the Mann-Whitney U test was used. Results were judged statistically significant if p < 0.05.ResultsAnalysis of the results showed a significantly higher number of ICAM-2 gene mRNA copies in ACS patients compared to healthy subjects (140920 ±105207 and 15023 ±14325, respectively). Furthermore, our results indicate a correlation between obesity (p = 0.012) and positive burdening family history (p = 0.041) and increased ICAM-2 levels in patients with ACS.ConclusionsIncreased ICAM-2 gene expression in ACS patients is probably symptomatic of endothelium dysfunction and may be responsible for intensified adhesion and aggregation processes as well as for appearance of acute coronary syndrome. These results indicate a correlation between obesity and burdening family history on the one hand, and increased ICAM-2 levels in patients with ACS, on the other.

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“…There appears to be a link between extensive CAE and a more profound inflammatory state, which may also be responsible for abnormalities in the coronary microcirculation, since patients with iCAE have abnormal distal perfusion, even though the epicardial flow is normal, and the degree of CAE extension is associated with the seric concentration of soluble adhesion molecules, which in turn are independently associated with coronary slow flow [51][52][53].…”

Section: Role Of Inflammationmentioning

confidence: 99%

Isolated coronary artery ectasia presenting as inferior-posterior STEMI—a case-based state-of-the-art review of the current literature

Giucă,

Rocsoreanu,

Şerban

et al. 2023

Romanian Journal of Cardiology

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Background This review is based on the case of a 71-year-old female patient, with cardiovascular risk factors, who was referred for emergency cardiological evaluation after experiencing severe anterior chest pain that had lasted for more than 5 hours at the time of admission. A diagnosis of inferior-posterior ST-segment elevation myocardial infarction was established, and emergency coronary angiography was performed. It revealed severe, diffuse dilation of the entire arterial coronary tree with slow flow and the presence of a large quantity of thrombotic material in the right coronary artery. Thromboaspiration was deemed unfit since the operator believed that there was a high risk of distal embolization with subsequent no-reflow, when passing with the catheter. As such, the patient started receiving anticoagulant therapy, and after one month she was scheduled for a control angiogram. The follow-up coronary angiography identified complete dissolution of the thrombus from the right coronary artery and a moderate stenosis in the distal segment, so no stent implantation was required. Rationale for review After performing a complete and comprehensive differential diagnosis, presence of isolated coronary artery ectasia was established. Coronary artery ectasia is a rare disease, usually found incidentally during coronary angiograms performed for other indications (chronic and acute coronary syndromes) with a vast etiology and complex pathophysiology. Because there are common morphopathologic pathways between coronary artery ectasia and atherosclerotic coronary artery disease, the clinical presentation of the former might have similar characteristics with the latter, but the management and prognosis of these patients is much less studied compared to the patients suffering from different phenotypes of coronary atherosclerosis. This review aims to summarize the etiopathogenesis, clinical presentation, diagnostic modalities, and different management pathways of coronary artery ectasia.

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Inverse correlation between coronary blood flow velocity and sICAM-1 level observed in ischemic heart disease patients

Cited by 9 publications

References 28 publications

The Association of Social Status and Blood Pressure With Markers of Vascular Inflammation

The Association of Social Status and Blood Pressure With Markers of Vascular Inflammation

Expression analysis of intercellular adhesion molecule-2 (ICAM-2) in the context of classical cardiovascular risk factors in acute coronary syndrome patients

Isolated coronary artery ectasia presenting as inferior-posterior STEMI—a case-based state-of-the-art review of the current literature

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