2019
DOI: 10.1016/j.bone.2019.03.038
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Inverse correlation between trabecular bone volume and bone marrow adipose tissue in rats treated with osteoanabolic agents

Abstract: There is currently an unmet clinical need for improved treatments for skeletal diseases such as osteoporosis and cancer-induced bone disease. This is due in part to a paucity of novel targets and an incomplete understanding of the mechanisms of action for established therapies. We defined the effects of anabolic treatments on bone and the bone marrow adipocyte (BMA). Sclerostinneutralizing antibodies (Scl-Ab, romosozumab, human parathyroid hormone (hPTH, 1-34), and hPTH/hPTHrP analogues (eg. teriparatide and a… Show more

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Cited by 26 publications
(30 citation statements)
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“…Well-studied osteoanabolic treatments are human parathyroid hormone (hPTH) and sclerostin antibody (Scl-Ab). Both of these agents stimulate bone formation, but through different modes of action (40, 41). Scl-Ab increases bone formation by inhibiting sclerostin binding to lipoprotein receptor protein (LRP) 5/6 that inhibits canonical WNT signaling and subsequently activating SSC differentiation into osteoblasts (40, 41).…”
Section: In Vitro Irradiation Of Skeletal Stem Cells Alters Differentmentioning
confidence: 99%
See 3 more Smart Citations
“…Well-studied osteoanabolic treatments are human parathyroid hormone (hPTH) and sclerostin antibody (Scl-Ab). Both of these agents stimulate bone formation, but through different modes of action (40, 41). Scl-Ab increases bone formation by inhibiting sclerostin binding to lipoprotein receptor protein (LRP) 5/6 that inhibits canonical WNT signaling and subsequently activating SSC differentiation into osteoblasts (40, 41).…”
Section: In Vitro Irradiation Of Skeletal Stem Cells Alters Differentmentioning
confidence: 99%
“…Both of these agents stimulate bone formation, but through different modes of action (40, 41). Scl-Ab increases bone formation by inhibiting sclerostin binding to lipoprotein receptor protein (LRP) 5/6 that inhibits canonical WNT signaling and subsequently activating SSC differentiation into osteoblasts (40, 41). Scl-Ab also suppresses bone resorption through inhibitory effects on osteoclastogenesis regulators (4143).…”
Section: In Vitro Irradiation Of Skeletal Stem Cells Alters Differentmentioning
confidence: 99%
See 2 more Smart Citations
“…While the BM is a particularly difficult organ for histological analysis, in part due to the soft and hard tissue that are juxtaposed, the overall analysis of its multiple components (bone, blood progenitors, adipocytes) provides important information to understand its physiopathology. Available histomorphometric analysis programs usually specialize in detecting individual components, and either require targeted staining protocols to detect specific components within the bone fraction, or use less adapted tools from the extramedullary adipose field to quantify the BMAd fraction [ (8,9,(20)(21)(22)(23)(24)(25)(26)(27); and also reviewed in (6)]. In order to reduce inter-observer variability and to quantify sections of entire murine bones rather than representative fields of view, automation and standardization of methods are key.…”
Section: Introductionmentioning
confidence: 99%