Inverse material characterisation of human aortic tissue for traumatic injury in motor vehicle crashes

Gaur, Piyush; Sharma, Sanyam; Kumar, Devendra; Chawla, Anoop; Mukherjee, Sudipto; Jain, Mohit; Mayer, Christian; Chitteti, Ravi Kiran; Ghosh, Pronoy; Malhotra, Rajesh; Lalwani, Sanjeev

doi:10.1080/13588265.2020.1807678

Cited by 3 publications

(2 citation statements)

References 72 publications

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“…The circumferential direction is the primary orientation of the aortic laminar unit ( O Connell et al, 2008 ; Holzapfel and Ogden, 2018 ), and the mechanical characteristics of the aorta exhibit anisotropy ( Sigaeva et al, 2019 ; Pukaluk et al, 2022 ). The result showed that the parameters of the circumferential direction were greater than the axial direction group, in line with previous studies ( Gaur et al, 2020 ), but there were no significant differences in the abdominal aorta. It may be due to an increased gradually proportion of collagen fibers from proximal to distal, which are predominantly aligned in a longitudinal direction ( Assoul et al, 2008 ).…”

Section: Discussionsupporting

confidence: 92%

“…The circumferential direction is the primary orientation of the aortic laminar unit (O Connell et al, 2008;Holzapfel and Ogden, 2018), and the mechanical characteristics of the aorta exhibit anisotropy (Sigaeva et al, 2019;Pukaluk et al, 2022). The result showed that the parameters of the circumferential direction were greater than the axial direction group, in line with previous studies (Gaur et al, 2020), but there were no significant differences in the Comparing the effect of gender on mechanical parameters. (A), (B), (C), (D), (E), and (F) denote the ultimate stress (σ p ), ultimate strain (ε p ), ultimate modulus of elasticity (E 2) , middle stress point (σ t ), middle strain point (ε t ), and initial modulus of elasticity (E 0 ), respectively.…”

Section: The Effect Of Different Test Directions On Parameterssupporting

confidence: 87%

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A study on the ultimate mechanical properties of middle-aged and elderly human aorta based on uniaxial tensile test

Chen,

Zhao,

et al. 2024

Front. Bioeng. Biotechnol.

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Background:The mechanical properties of the aorta are particularly important in clinical medicine and forensic science, serving as basic data for further exploration of aortic disease or injury mechanisms.Objective:To study the influence of various factors (age, gender, test direction, anatomical location, and pathological characteristics) on the mechanical properties and thickness of the aorta.Methods:In this study, a total of 24 aortas (age range: 54–88 years old) were collected, one hundred and seventy-four dog-bone-shaped samples were made, and then the uniaxial tensile test was run, finally, pathological grouping was performed through histological staining.Results:Atherosclerotic plaques were mainly distributed near the openings of blood vessel branches. The distribution was most severe in the abdominal aorta, followed by the aortic arch. Aortic atherosclerosis was a more severe trend in the male group. In the comparison of thickness, there were no significant differences in age (over 50 years) and test direction, the average thickness of the aorta was greater in the male group than the female group and decreased progressively from the ascending aorta to the abdominal aorta. Comparing the mechanical parameters, various parameters are mainly negatively correlated with age, especially in the circumferential ascending aorta (εp “Y = −0.01402*X + 1.762, R2 = 0.6882”, εt “Y = −0.01062*X + 1.250, R2 = 0.6772”); the parameters of males in the healthy group were larger, while the parameters of females were larger in atherosclerosis group; the aorta has anisotropy, the parameters in the circumferential direction were greater than those in the axial direction; the parameters of the ascending aorta were the largest in the circumferential direction, the ultimate stress [σp “1.69 (1.08,2.32)”] and ultimate elastic modulus [E2“8.28 (6.67,10.25)”] of the abdominal aorta were significantly larger in the axial direction; In the circumferential direction, the stress [σp “2.2 (1.31,3.98)”, σt “0.13 (0.09,0.31)”] and ultimate elastic modulus (E2 “14.10 ± 7.21”) of adaptive intimal thickening were greater than those of other groups, the strain (εp “0.82 ± 0.17”, εt “0.53 ± 0.14”) of pathological intimal thickening was the largest in the pathological group.Conclusion:The present study systematically analyzed the influence of age, sex, test direction, anatomical site, and pathological characteristics on the biomechanical properties of the aorta, described the distribution of aortic atherosclerosis, and illustrated the characteristics of aortic thickness changes. At the same time, new insights into the grouping of pathological features were presented.

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Section: Discussionsupporting

confidence: 92%

“…The circumferential direction is the primary orientation of the aortic laminar unit (O Connell et al, 2008;Holzapfel and Ogden, 2018), and the mechanical characteristics of the aorta exhibit anisotropy (Sigaeva et al, 2019;Pukaluk et al, 2022). The result showed that the parameters of the circumferential direction were greater than the axial direction group, in line with previous studies (Gaur et al, 2020), but there were no significant differences in the Comparing the effect of gender on mechanical parameters. (A), (B), (C), (D), (E), and (F) denote the ultimate stress (σ p ), ultimate strain (ε p ), ultimate modulus of elasticity (E 2) , middle stress point (σ t ), middle strain point (ε t ), and initial modulus of elasticity (E 0 ), respectively.…”

Section: The Effect Of Different Test Directions On Parameterssupporting

confidence: 87%

A study on the ultimate mechanical properties of middle-aged and elderly human aorta based on uniaxial tensile test

Chen,

Zhao,

et al. 2024

Front. Bioeng. Biotechnol.

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Quantitative study of aortic strain injuries originating from traffic accidents

Yang

Wang

Liu

2022

Forensic Sci Med Pathol

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Experimental Protocols to Test Aortic Soft Tissues: A Systematic Review

Valente,

Mourato,

Xavier

et al. 2024

Bioengineering

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Experimental protocols are fundamental for quantifying the mechanical behaviour of soft tissue. These data are crucial for advancing the understanding of soft tissue mechanics, developing and calibrating constitutive models, and informing the development of more accurate and predictive computational simulations and artificial intelligence tools. This paper offers a comprehensive review of experimental tests conducted on soft aortic tissues, employing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, based on the Scopus, Web of Science, IEEE, Google Scholar and PubMed databases. This study includes a detailed overview of the test method protocols, providing insights into practical methodologies, specimen preparation and full-field measurements. The review also briefly discusses the post-processing methods applied to extract material parameters from experimental data. In particular, the results are analysed and discussed providing representative domains of stress–strain curves for both uniaxial and biaxial tests on human aortic tissue.

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Inverse material characterisation of human aortic tissue for traumatic injury in motor vehicle crashes

Cited by 3 publications

References 72 publications

A study on the ultimate mechanical properties of middle-aged and elderly human aorta based on uniaxial tensile test

A study on the ultimate mechanical properties of middle-aged and elderly human aorta based on uniaxial tensile test

Quantitative study of aortic strain injuries originating from traffic accidents

Experimental Protocols to Test Aortic Soft Tissues: A Systematic Review

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