Inverse, Multiple and Sequential Sample Censuses

Chapman, Douglas G.

doi:10.21236/ad0005527

Cited by 63 publications

(48 citation statements)

References 7 publications

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“…56 Mark-recapture analysis followed the Lincoln-Petersen and Modified Petersen methods 57, 58 with 95% confidence intervals calculated following Chapman. 59 Burden analysis was performed in PLINK/SEQ to implement BURDEN and VTTEST with empirical P -values estimated using permutation. Genotyping of the replication and familial samples was performed by the Edinburgh Wellcome Trust Clinical Research Facility Genetics Core using TaqMan SNP genotyping assay C__33950433_10 with concurrent genotyping of known heterozygotes.…”

Section: Methodsmentioning

confidence: 99%

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits

et al. 2013

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A balanced t(1;11) translocation that transects the Disrupted in schizophrenia 1 (DISC1) gene shows genome-wide significant linkage for schizophrenia and recurrent major depressive disorder (rMDD) in a single large Scottish family, but genome-wide and exome sequencing-based association studies have not supported a role for DISC1 in psychiatric illness. To explore DISC1 in more detail, we sequenced 528 kb of the DISC1 locus in 653 cases and 889 controls. We report 2718 validated single-nucleotide polymorphisms (SNPs) of which 2010 have a minor allele frequency of <1%. Only 38% of these variants are reported in the 1000 Genomes Project European subset. This suggests that many DISC1 SNPs remain undiscovered and are essentially private. Rare coding variants identified exclusively in patients were found in likely functional protein domains. Significant region-wide association was observed between rs16856199 and rMDD (P=0.026, unadjusted P=6.3 × 10−5, OR=3.48). This was not replicated in additional recurrent major depression samples (replication P=0.11). Combined analysis of both the original and replication set supported the original association (P=0.0058, OR=1.46). Evidence for segregation of this variant with disease in families was limited to those of rMDD individuals referred from primary care. Burden analysis for coding and non-coding variants gave nominal associations with diagnosis and measures of mood and cognition. Together, these observations are likely to generalise to other candidate genes for major mental illness and may thus provide guidelines for the design of future studies.

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Section: Methodsmentioning

confidence: 99%

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits

et al. 2013

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“…With three variables known, we can solve for the number of deer in the entire population: n = (m1*n2)/m2. This formula is known to overestimate the true size of the population for small sample sizes[23]. To minimize bias in our analysis we use the related equation n = [{(m1+1)*(n2+1)}/(m2+l)]-1 [23].…”

Section: Methodsmentioning

confidence: 99%

Modified capture–recapture estimates of the number of families with Lynch syndrome in Central Ohio

et al. 2018

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Past methods for estimating the population frequency of familial cancer syndromes have used cases and controls ignoring the familial nature of genetic disease. In this study we modified the capture-recapture method from ecology to estimate the number of families in central Ohio with Lynch syndrome (LS). We screened 1566 colorectal cancer cases and 545 endometrial cancer cases in central Ohio from 1999 to 2005 and identified 58 with LS. We screened an additional 3346 colorectal and 342 endometrial cancer cases from 2013 to 2016 and identified 149 with LS. We found 12 LS mutations shared between families observed in the first and second studies. We identified three individuals between studies who were closely related and eight who were more distantly related. We used identified family relationships and genetic test results to estimate family size and structure. Applying a modified capture-recapture method we estimate 1693 3-generation families in the area who have 288 unique LS causing mutations. Comprehensive colorectal and endometrial cancer screening will take about 20 years to identify 50% of families with LS. This is the first time that the capture-recapture method has been applied to estimate the burden of families with a specific heritable disease. Family structure reveals the potential extent of prevention and the time necessary to identify a proportion of families with LS.

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“…In our study, the population was not closed and the surveillance period was considered a single continuous captureÀmarkÀrecapture occasion. In such a situation, because there is no unique convincing solution to the problem of estimating the population size, we applied both the JollyÀSeber model (Jolly 1965;Seber 1965) and the inverse multiple sample census (Chapman 1952). Though the JollyÀSeber model allows the population size to be estimated at each sampling step, migration cannot be separated from birth and death events without some additional information.…”

Section: Statistical Analysis: Estimation Of Abundance and Prevalencementioning

confidence: 99%

Influenza A virus prevalence and its implications on survival in mallard

Giammarino¹,

Quatto

Rizzo³

et al. 2014

Israel J Ecol Evol

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Avian influenza is an infectious viral disease of birds caused by type A strains of the influenza virus. Aquatic bird species have adapted to carry and transmit a wide range of influenza strains in nature. Here we report the results of a 4.5-year monitoring program for Orthomyxovirus prevalence in a population of wild mallard (Anas plathyrynchos) in northwestern Italy. To determine whether Orthomyxovirus prevalence affects survival, we used MARK software to compare the survival of AIV-positive versus AIV-negative birds. Prevalence rates and variance were estimated using inverse sampling method. The prevalence rate of influenza A virus was 4.3% (SE 0.00116) and lifespan was shorter (29.8%) for the young infected birds than for the young non-infected birds.

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Inverse, Multiple and Sequential Sample Censuses

Cited by 63 publications

References 7 publications

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits

Modified capture–recapture estimates of the number of families with Lynch syndrome in Central Ohio

Influenza A virus prevalence and its implications on survival in mallard

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