Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis

Paapstel, Kaido; Kals, Jaak; Eha, Jaan; Tootsi, Kaspar; Ottas, Aigar; Piir, Anneli; Jakobson, Meelis; Lieberg, J.; Zilmer, Mihkel

doi:10.1016/j.numecd.2017.07.011

Cited by 86 publications

(68 citation statements)

References 37 publications

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“…Previously, lower concentrations of lysophosphatidylcholines have been observed in obesity and type 2 diabetes mellitus (Barber et al 2012 ), and might directly affect insulin resistance state (Motley et al 2002 ). Furthermore, an inverse relationship between serum lysophosphatidylcholines and vascular damage and heart rate was observed in patients with atherosclerosis (Paapstel et al 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease

et al. 2019

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Background We aimed to identify novel metabolite and lipid signatures connected with the metabolic syndrome in a Dutch middle-aged population. Methods 115 individuals with a metabolic syndrome score ranging from 0 to 5 [50 cases of the metabolic syndrome (score ≥ 3) and 65 controls] were enrolled from the Leiden Longevity Study, and LC/GC–MS metabolomics and lipidomics profiling were performed on fasting plasma samples. Data were analysed with principal component analysis and orthogonal projections to latent structures (OPLS) to study metabolite/lipid signatures associated with the metabolic syndrome. In addition, univariate analyses were done with linear regression, adjusted for age and sex, for the study of individual metabolites/lipids in relation to the metabolic syndrome. Results Data was available on 103 metabolites and 223 lipids. In the OPLS model with metabolic syndrome score (Y-variable), 9 metabolites were negatively correlated and 26 metabolites (mostly acylcarnitines, amino acids and keto acids) were positively correlated with the metabolic syndrome score. In addition, a total of 100 lipids (mainly triacylglycerides) were positively correlated and 10 lipids from different lipid classes were negatively correlated with the metabolic syndrome score. In the univariate analyses, the metabolic syndrome (score) was associated with multiple individual metabolites (e.g., valeryl carnitine, pyruvic acid, lactic acid, alanine) and lipids [e.g., diglyceride(34:1), diglyceride(36:2)]. Conclusion In this first study on metabolomics/lipidomics of the metabolic syndrome, we identified multiple novel metabolite and lipid signatures, from different chemical classes, that were connected to the metabolic syndrome and are of interest to cardiometabolic disease biology. Electronic supplementary material The online version of this article (10.1007/s11306-019-1484-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease

et al. 2019

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“…In particular, CM-d18:1/16:0 was consistently associated with higher necrotic core fractions on IVUS-VH, higher LCBI on NIRS and higher incident CVD. Paapstel et al recently investigated serum PC and LPC species in relation to arterial stiffness, hemodynamics, and endothelial dysfunction in symptomatic patients with atherosclerosis and in healthy controls [33]. Decreased serum levels of several individual PC and LPC species (e.g., PC-diacyl-28:1, PC-diacyl-30:0, PC-diacyl-32:2, PC-acyl-alkyl-30:0 and PC-acyl-alkyl-34:2, LPC-acyl-18:2) were observed in patients with atherosclerosis in comparison to healthy subjects.…”

Section: Atherosclerosismentioning

confidence: 99%

Lipidomic insight into cardiovascular diseases

Kohno

Keenan

Ntambi

et al. 2018

Biochemical and Biophysical Research Communications

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Cardiovascular disease is a primary cause of mortality worldwide. Therefore, it is of major interest to identify sensitive molecular markers that predict cardiovascular events and point to therapeutic strategies that will increase lifespans. Dysregulated lipid metabolism is recognized as an established risk factor in cardiovascular diseases. However, it is still largely unknown which specific lipid molecular species reflect cardiovascular risk. In addition, understanding the whole lipidome signature in vascular pathophysiology is challenging. Recent advancements of mass-spectrometry allow researchers to detect each individual lipid species from unbiased small samples. In this review, we update the current research on lipidomic approaches in cardiovascular diseases.

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“…Additionally, previous metabolomics and transcriptomics-based experiment revealed that LPCs (16:0), (18:0), and (18:1) were significantly elevated in the aortas of apolipoprotein E knockout mice during early atherosclerosis (Schmitz and Ruebsaamen, 2010). However, other recent report showed that some serum LPCs, such as (16:0) and (18:0), were inversely related to cfPWV, heart rate, asymmetric dimethylarginine (ADMA) and ADMA/arginine in patients with symptomatic atherosclerosis as compared to the controls (Paapstel et al, 2018). Additional research and clinical studies are required to reconcile these conflicting results presented in the literature.…”

Section: Discussionmentioning

confidence: 90%

Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension

Polonis

Wawrzyniak

Daghir-Wojtkowiak

et al. 2020

Front. Mol. Biosci.

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Arterial stiffening is a hallmark of early vascular aging (EVA) syndrome and an independent predictor of cardiovascular morbidity and mortality. In this case-control study we sought to identify plasma metabolites associated with EVA syndrome in the setting of hypertension. An untargeted metabolomic approach was used to identify plasma metabolites in an age-, BMI-, and sex-matched groups of EVA (n = 79) and non-EVA (n = 73) individuals with hypertension. After raw data processing and filtration, 497 putative compounds were characterized, out of which 4 were identified as lysophosphaditylcholines (LPCs) [LPC (18:2), LPC (16:0), LPC (18:0), and LPC (18:1)]. A main finding of this study shows that identified LPCs were independently associated with EVA status. Although LPCs have been shown previously to be positively associated with inflammation and atherosclerosis, we observed that hypertensive individuals characterized by 4 down-regulated LPCs had 3.8 times higher risk of EVA compared to those with higher LPC levels (OR = 3.8, 95% CI 1.7-8.5, P < 0.001). Our results provide new insights into a metabolomic phenotype of vascular aging and warrants further investigation of negative association of LPCs with EVA status. This study suggests that LPCs are potential candidates to be considered for further evaluation and validation as predictors of EVA in patients with hypertension.

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Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis

Cited by 86 publications

References 37 publications

Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease

Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease

Lipidomic insight into cardiovascular diseases

Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension

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