Inverse Relationship Between Adiponectin Levels and Subclinical Carotid Atherosclerosis in Patients Undergoing Coronary Artery Bypass Grafting

Kiriş, İlker; Tekin, İlker; Yeşildağ, Ahmet; Vural, Hüseyín; Oyar, Orhan; Sirin, Burcu; Okutan, Hüseyin; İbrişim, Erdoǧan

doi:10.1536/ihj.47.855

Cited by 14 publications

(10 citation statements)

References 34 publications

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“…The inverse correlation between serum adiponectin concentrations and carotid IMT (intima-media thickness), a well-established measure of subclinical atherosclerosis, has been reported in a number of studies in both healthy subjects and patients with T2DM [38,39]. In a study of 140 obese juveniles (mean age, 13.5 years), serum levels of adiponectin were correlated negatively with carotid IMT, even after controlling for BMI, the insulin resistance index, cholesterol, triacylglycerols (triglycerides), blood pressure, hs-CRP (high-sensitivity C-reactive protein), gender and age [40].…”

Section: Clinical Datamentioning

confidence: 90%

Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention

et al. 2008

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Adiponectin is a major adipocyte-secreted adipokine abundantly present in the circulation as three distinct oligomeric complexes. In addition to its role as an insulin sensitizer, mounting evidence suggests that adiponectin is an important player in maintaining vascular homoeostasis. Numerous epidemiological studies based on different ethnic groups have identified adiponectin deficiency (hypoadiponectinaemia) as an independent risk factor for endothelial dysfunction, hypertension, coronary heart disease, myocardial infarction and other cardiovascular complications. Conversely, elevation of circulating adiponectin concentrations by either genetic or pharmacological approaches can alleviate various vascular dysfunctions in animal models. Adiponectin exerts its vasculoprotective effects through its direct actions in the vascular system, such as increasing endothelial NO production, inhibiting endothelial cell activation and endothelium-leucocyte interaction, enhancing phagocytosis, and suppressing macrophage activation, macrophage-to-foam cell transformation and platelet aggregation. In addition, adiponectin reduces neointima formation through an oligomerization-dependent inhibition of smooth muscle proliferation. The present review highlights recent research advances in unveiling the molecular mechanisms that underpin the vascular actions of adiponectin and discusses the potential strategies of using adiponectin or its signalling pathways as therapeutic targets to combat obesity-related metabolic and vascular diseases.

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Section: Clinical Datamentioning

confidence: 90%

Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention

et al. 2008

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“…Hypoadiponectinemia has been correlated with increased atherosclerosis-related compounds, including adipocyte fatty-acid-binding protein (A-FABP), lipocalin-2, as well as other markers of oxidative stress [43,44]. The compound has great potential as a marker for atherosclerotic disease, its decrease having been shown to be predictive of acute coronary syndrome, myocardial infarction, coronary artery disease, and ischemic cerebrovascular disease [45,46].…”

Section: Adiponectinmentioning

confidence: 99%

Adipose Tissue: The New Endocrine Organ? A Review Article

et al. 2008

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Fat is either white or brown, the latter being found principally in neonates. White fat, which comprises adipocytes, pre-adipocytes, macrophages, endothelial cells, fibroblasts, and leukocytes, actively participates in hormonal and inflammatory systems. Adipokines include hormones such as leptin, adiponectin, visfatin, apelin, vaspin, hepcidine, chemerin, omentin, and inflammatory cytokines, including tumor necrosis factor alpha (TNF), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator protein (PAI). Multiple roles in metabolic and inflammatory responses have been assigned to adipokines; this review describes the molecular actions and clinical significance of the more important adipokines. The array of adipokines evidences diverse roles for adipose tissue, which looms large in the mediators of inflammation and metabolism. For this reason, treating obesity is more than a reduction of excess fat; it is also the treatment of obesity's comorbidities, many of which will some day be treated by drugs that counteract derangements induced by adipokine excesses.

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“…The association between adiponectin and carotid plaques has been investigated in a few studies, but to our knowledge, none has found a significant association 10,11 . In the Health Professionals Study, a doubling of baseline adiponectin level was reported to be associated with a statistically significant 20% reduction in myocardial infarction (MI) risk in multivariate analyses, after adjustment for age, smoking, hypertension history, lipids, glycemic control, and C-reactive protein (CRP) 12 .…”

Section: Original Papermentioning

confidence: 99%

The association between serum adiponectin and carotid intima media thickness in community based cohort in Korea: The ARIRANG study

Ahn

Koh

Kim

et al. 2011

Mol. Cell. Toxicol.

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Growing body of evidence suggests an association between circulating adiponectin and the development of atherosclerosis. However most of these studies have been performed with healthy subjects with relatively small sample size or patients with preexisting cardiovascular diseases. The results obtained are inconstant for an independent association between adiponectin and subclinical atherosclerosis. We aimed to evaluate the association between circulating adiponectin and carotid intima media thickness (CIMT) in a large sample of individuals from the community. We performed a non-diabetic community based cohort study conducted on a healthy Korean adults (age¤40 years) population. The serum adiponectin concentrations were measured by a radioimmunoassay. The mean adiponectin level was significantly lower in subjects with high CIMT defined by ¤0.9 mm than those with low CIMT (9.18 vs. 10.44 μg/mL, P=0.03). The adiponectin level was correlated negatively with waist circumference (r=-0.27), body mass index (r=-0.21), systolic blood pressure (r=-0.11), diastolic blood pressure (r=-0.10), triglyceride (r=-0.30), LDL-cholesterol (r=-0.02), glucose (r=-0.16), insulin (r=-0.17), homeostasis assessment-insulin resistance (r=-0.23) and C-reactive protein (r=-0.11), and correlated positively with HDL cholesterol (r=0.30) (all P⁄0.05). Adiponectin was significantly associated with CIMT independently of age, sex, and all metabolic risk factors (R 2 =0.14, P=0.04). In conclusion, serum adiponectin levels are independently associated with CIMT as a surrogate of subclinical atherosclerosis in a non-diabetic community based cohort.Obesity and overweight conditions pose a major risk for a number of comorbidities including atherosclerotic diseases. Recent advances in obesity research strongly indicate that adipose tissue is an active endocrine organ that secretes multiple bioactive factors categorized as adipokines 1,2 . The adipokines include a large number of cytokines (e.g. tumor necrosis factor-α and interleukin-6), chemokines (e.g. interleukin-8 and monocyte chemoattractant protein-1) and hormones (e.g. leptin, resistin and adiponectin) 3,4 . Adipokines released by adipose tissue can target distant organs, such as liver, skeletal muscle and hypothalamus. These adipokines impact the atherogenic environment of the

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Inverse Relationship Between Adiponectin Levels and Subclinical Carotid Atherosclerosis in Patients Undergoing Coronary Artery Bypass Grafting

Cited by 14 publications

References 34 publications

Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention

Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention

Adipose Tissue: The New Endocrine Organ? A Review Article

The association between serum adiponectin and carotid intima media thickness in community based cohort in Korea: The ARIRANG study

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