Inverse relationship of cardioankle vascular index with BMI in healthy Japanese subjects: a cross-sectional study

Nagayama, Daiji; Imamura, Hajime; Sato, Yuta; Yamaguchi, Takashi; Ban, Noriko; Kawana, Hidetoshi; Ohira, Masahiro; Saiki, Atsuhito; Shirai, Kohji; Tatsuno, Ichiro

doi:10.2147/vhrm.s119646

Cited by 48 publications

(61 citation statements)

References 71 publications

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“…In addition, we have found a negative correlation between BMI and CAVI in the overall population and in both genders. Nagayama et al found that an inverse correlation between BMI and CAVI in healthy middle-aged subjects, and they hypothesized that systemic accumulation of adipose tissue, per se, leads to reduced arterial stiffness [ 44 ]. In another study of middle-aged and elderly Chinese subjects, an inverse correlation between BMI and CAVI was also observed [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…In another study of middle-aged and elderly Chinese subjects, an inverse correlation between BMI and CAVI was also observed [ 21 ]. It seems that high BMI values do not always mean high arterial stiffness, which is probably related to the distribution of body fat, as the absolute amount of adipose tissue does not increase the risk of cardiovascular disease in many overweight people [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

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Gender-specific association of metabolic syndrome and its components with arterial stiffness in the general Chinese population

Yue¹,

Liu²,

He³

et al. 2017

PLoS ONE

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ObjectivesMetabolic syndrome (MS) is considered to be a cluster of interrelated risk factors for metabolism, which may increase arterial stiffness and cardiovascular morbidity. The cardio-ankle vascular index (CAVI) is a reliable indicator of arterial stiffness and early arteriosclerosis. The main objective of this study is to evaluate the gender-specific relationship between MS and CAVI in the general Chinese population.MethodsA total of 1,301 subjects aged 20 to 60 years participated in this study. CAVI was measured noninvasively using a Vasera VS-1000 device. Blood samples and waist circumference were examined to identify metabolic syndrome according to the criteria set forth in the 2009 Joint Scientific Statement.ResultsThe prevalence of MS in the study subjects was 17.4% (30.7% in males and 7.0% in females, P < 0.001). CAVI values were significantly higher in MS subjects than in non-MS subjects and increased linearly as the number of MS components increased in females, but not in males. Using multiple regression analysis, we found that BMI was correlated with CAVI in the overall population and in both genders, and that high-density lipoprotein cholesterol (HDL-C) was associated with CAVI in males, while the number of MS components was related to CAVI in females. CAVI values increased linearly with age in both genders (P-trend < 0.001 for both), and this correlation was stronger in males than in females.ConclusionsThere are gender-specific differences in the association of MS and CAVI. First, the effects of the number of MS components on CAVI are stronger in females than in males. Second, the effect of each MS component on arterial stiffness may differ in relation to gender. In addition, aging affects arterial stiffness more severely in males, and the increase in arterial stiffness tends to occur at a younger age in males than in females. Larger samples and longitudinal studies are needed to further confirm our results in the future.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gender-specific association of metabolic syndrome and its components with arterial stiffness in the general Chinese population

Yue¹,

Liu²,

He³

et al. 2017

PLoS ONE

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“…tionship between CAVI and BMI in healthy individuals with a mean age of 47.1 years 50) . Other investigators have also reported a similar inverse relationship between CAVI and BMI in 2,354 adults ranging in age from 35 to 74 years, with a mean age of 61.4 years 51) .…”

Section: General Obesitymentioning

confidence: 99%

Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers

Sugiura

Dohi

Takagi

et al. 2020

JAT

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The official journal of the Japan Atherosclerosis Society and the Asian Pacific Society of Atherosclerosis and Vascular Diseases Original Article Aim: Obesity is a social problem due to the prevalence of the Western lifestyle. In particular, visceral fat accumulation, which is a main component of metabolic syndrome, is closely associated with the progression of atherosclerosis. This study aimed to investigate the relationships of obesity-related indices and metabolic syndrome with subclinical atherosclerosis in middle-aged untreated workers. Methods: Employees undergoing their periodic health checkup but without previous cardiovascular events or cardiovascular medications were enrolled in this study (n 7,750). Body mass index (BMI), percent body fat, waist circumference, and visceral fat area were evaluated as obesity-related indices. Assessment of visceral fat area was performed by computed tomography (CT). Subclinical atherosclerosis was assessed by measuring arterial stiffness using cardio-ankle vascular index (CAVI) and by ultrasound examination of carotid intima-media thickness (IMT). Results: Obesity-related indices were significantly correlated with each other and were positively associated with carotid IMT but negatively associated with CAVI in multivariate regression analysis. In a logistic regression analysis including CAVI and carotid IMT simultaneously, CAVI was negatively associated, but carotid IMT was positively associated, with obesity defined by each obesity-related index. In contrast, both CAVI and carotid IMT were positively associated with the presence of metabolic syndrome based on visceral fat accumulation. Conclusions: Obesity-related indices were negatively associated with CAVI and positively associated with carotid IMT in middle-aged untreated workers, while both CAVI and carotid IMT were worsened in the presence of metabolic syndrome. index (BMI) is simply calculated by anthropometric measurements of body weight and body height and is conveniently and widely used for the diagnosis of obesity 1-3). The World Health Organization (WHO) defines the conditions of being overweight and obesity based on a BMI ≥ 25 kg/m 2 and ≥ 30 kg/m 2 , respectively, and Copyright©2020 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

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“…Since PWV is known to be associated with blood pressure, CAVI has been developed to measure arterial stiffness, and the measurement is basically independent of blood pressure. In a recent study, however, CAVI is inversely associated with the BMI of both male and female 35) . This association is consistent with our findings, although the reason is still uncertain.…”

Section: Cavi Cavimentioning

confidence: 76%

Reactive hyperemia index can screen endothelial dysfunction in obese subjects with non-alcoholic fatty liver disease

et al. 2018

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Background and Aims: Reactive hyperemia-peripheral arterial tonometry (RH-PAT) has been developed to detect early stage vascular dysfunction. Recent studies have suggested that Reactive hyperemia index (RHI) assessed using RH-PAT could be used to predict the mortality of subjects with high risks for cardiovascular events. On the other hand, carotid intima-media thickness (IMT), pulse wave velocity (PWV), and/or cardio-ankle vascular index (CAVI) have been used as screening tools for vascular disorders. Since obesity and metabolic syndrome are the risk factors for cardiovascular events, we aimed to examine the association of RHI, CAVI, and carotid artery plaque scores with the body mass index (BMI). Methods: The participants of this study were 39 Japanese subjects who were admitted at the Department of Liver Disease of Shimane University Hospital between August and December 2016 (mean age, 62 years). RH-PAT findings, CAVI, and carotid IMT were evaluated, and their associations with BMI were analyzed. Carotid IMT and plaque score (PS) were evaluated by ultrasonography following the standard protocol. A score of less than 1.67 was defined as a low RHI. Results: The PS was associated with age (r=0.511, p<0.0001) but not with BMI. Interestingly, CAVI had a positive association with age (r=0.706, p<0.0001) and an inverse association with BMI (r=−0.511, p<0.0001). In contrast, RHI had no significant association with age and BMI. Among 14 patients with non-alcoholic steatohepatitis (NASH) or non-alcoholic fatty liver disease (NAFLD) with BMI! 25, only one patient had high CAVI (>9.0) whereas 6 patients had low RHI. Conclusions: NASH/NAFLD subjects, especially those with obesity, are good candidates for RH-PAT examination to detect early stage of vascular failure.

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Inverse relationship of cardioankle vascular index with BMI in healthy Japanese subjects: a cross-sectional study

Cited by 48 publications

References 71 publications

Gender-specific association of metabolic syndrome and its components with arterial stiffness in the general Chinese population

Gender-specific association of metabolic syndrome and its components with arterial stiffness in the general Chinese population

Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers

Reactive hyperemia index can screen endothelial dysfunction in obese subjects with non-alcoholic fatty liver disease

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