Introduction. The trigonometric moment problem stands at the source of several major streams in analysis. From it flow developments in function theory, in spectral representation of operators, in probability, in approximation, and in the study of inverse problems. Here we connect it also with a group of questions centering on entropy and prediction. In turn, this will suggest a simple approach, by way of orthogonal decomposition, to the moment problem itself.In statistical estimation, one often wants to guess an unknown probability distribution, given certain observations based on it. There are generally infinitely many distributions consistent with the data, and the question of which of these to select is an important one. The notion of entropy has been proposed here as the basis of a principle of salience which has received considerable attention. We will show that, in the context of spectral analysis, this idea is linked to a certain question of prediction by the trigonometric moment problem, and that all three strongly illuminate one another. The phenomena we describe are known, but our object is to unify them conceptually and to reduce the analytic intricacy of the arguments. To this end, we give a completely elementary discussion, virtually free of calculation, which shows that all the facts, including those concerning the moment problem, can be understood as direct consequences of orthogonal decomposition in a finite-dimensional space. We then describe how, in its continuous version, this leads to a view of second-order Sturm-Liouville differential equations, and conclude with some questions concerning the connection between combinatorial ideas and orthogonality in this problem.