In the present study, analytic signal amplitude (ASA) or total gradient (TG) inversion of self-potential anomalies has been carried out using very fast simulated annealing (VFSA) global optimization technique. The results of VFSA optimization demonstrate the application and efficacy of the proposed method for idealized synthetic hypothetical models and real single and multiple geological structures. The model parameters deciphered here are the amplitude coefficient (k), horizontal location (x 0), depth of the body (z), and shape (q). Inversion of the model parameter suggests that constraining the horizontal location and the shape factor offers the most reliable results. Investigation of convergence rate, histogram, and cross-plot examination suggest that the interpretation method developed for the selfpotential anomalies is stable and the model parameters are within the estimated ambiguity. Inversion of synthetic noise-free and noise-corrupted data for single structures and multiple structures in addition to real field information exhibits the viability of the method. The model parameters estimated by the present technique were in good agreement with the real parameters. The method has been used to invert two field examples (Sulleymonkoy anomaly, Ergani, Turkey, Senneterre area of Quebec, Canada) with application of subsurface mineralized bodies. This technique can be very much helpful for mineral or ore bodies investigation of idealized geobodies buried within the shallow and deeper subsurface.