Inverted Condyloma of Uterine Cervix: A Rare Condylomatous Lesion

Abstract

Human papillomavirus (HPV) is an epitheliotropic virus that can infect and cause disease of skin or mucosa at any site. HPV associated lesions can be broadly divided into cutaneous and mucous membrane lesions. Cutaneous lesions include: warts, Butcher's wart and epidermodysplasia verruciformis. The anogenital diseases, include warts (condyloma), dysplasia (cervical, vaginal, vulvar, anal), and squamous cell carcinoma. Here we are presenting a case report of a 27 year old female who was histologically diagnosed as inverted condyloma a rare condylomatous lesion involving the uterine cervix. KEYWORDS: Inverted Condyloma, uterine cervix. INTRODUCTION:Independent of the site or the type of lesion, the papilloma virus virion has a constant morphology and structure. 1 The virion is a non-enveloped 8 Kb long icosahedral structure of 55-60 nm diameter, which forms paracrystalline arrays in the nucleus of infected cells. 2 Epidemiologic studies show genital warts to be among the most common sexually transmitted diseases, after chlamydia and gonorrhea. The incidence of condyloma acuminatum has been steadily rising over the past three decades. 3 W.H.O. estimates that 630 million people are infected with genital HPV, resulting in a worldwide prevalence of 9-13%. 4 There is an inverse relationship between age and HPV prevalence in many countries. In some countries, cross-sectional and cohort studies have shown a U-shaped curve with a first peak in women under 30 years of age and a second peak in women aged 55-64 years. 5 It is believed that many sexually active adults are infected with HPV, but only 1±2% of them are found to have clinical lesions. Rest of the infections remain subclinical, with the latent HPV residing in the epithelial basal cells. 6 The most important risk factor for genital warts are decreasing age of first sexual intercourse, multiple sexual partners and clinical history of other venereal diseases. 7