Inverted J-Shaped Association of High-Sensitivity C-Reactive Protein with the Levels of Serum Uric Acid: Cross-Sectional and Longitudinal Analyses

Liu, Xing Zhen; Tian, Yan; Fan, Jia; Liu, Lian Yong

doi:10.2147/jir.s350057

Cited by 2 publications

(2 citation statements)

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“… 35 In our study, we found a statistically significant association between elevated levels of the well-known inflammatory marker hsCRP and hyperuricaemia in both genders. A similar association has been demonstrated in a handful of Chinese studies 36–38 and in a Nepalese study, 39 but has not previously been unequivocally demonstrated in Western populations. High level of hsCRP is a predictor of myocardial infarction, stroke, peripheral arterial disease and sudden cardiac death in healthy individuals without a history of cardiovascular disease and of recurrent events and death in patients with acute or stable coronary syndromes.…”

Section: Discussionsupporting

confidence: 82%

Hyperuricaemia: prevalence and association with mortality in an elderly Finnish population

et al. 2023

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ObjectiveTo establish the prevalence of hyperuricaemia in an elderly Finnish cohort and to assess its association with comorbidities and mortality.DesignProspective cohort study.SettingGood Ageing in Lahti Region study, Finland 2002–2012 (mortality data analysed until 2018).Participants2673 participants (mean age 64 years; 47% men).Primary and secondary outcome measuresPrevalence of hyperuricaemia in the study population was detected. Associations between hyperuricaemia and mortality were assessed using multivariable adjusted Cox proportional hazards models.MethodsData from a prospective, population-based study of elderly people (52–76 years) in the Lahti region, Finland, were used. Information on serum uric acid (SUA) levels as well as several other laboratory variables, comorbidities, lifestyle habits and socioeconomic factors was collected, and the association between SUA level and mortality in a 15-year follow-up period was analysed.ResultsOf 2673 elderly Finnish persons included in the study 1197 (48%) were hyperuricaemic. Hyperuricaemia was extremely prevalent in men (60%). There was an association between elevated SUA and mortality which remained after adjustment for potential confounding factors (age, gender, education, smoking status, body mass index, hypertension and dyslipidaemia). The adjusted HR for all-cause mortality among clearly hyperuricaemic individuals with SUA≥420 µmol/L compared with normouricaemic individuals (SUA<360 µmol/L) was 1.32 (95% CI 1.05 to 1.60) in women and 1.29 (95% CI 1.05 to 1.60) in men. In slightly hyperuricaemic individuals (SUA 360–420 µmol/L) the corresponding HRs were 1.03 (95% CI 0.78 to 1.35) and 1.11 (95% CI 0.89 to 1.39).ConclusionsHyperuricaemia is very prevalent in the elderly Finnish population and is independently associated with increased mortality.

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Section: Discussionsupporting

confidence: 82%

Hyperuricaemia: prevalence and association with mortality in an elderly Finnish population

et al. 2023

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“…13 Cross-sectional observational data (n=233 821) were extracted from our database of routine healthy screening (January 2013 to January 2021). 14,15 To exclude the influence of drugs on BP, lipid parameters, and blood cell parameters, those who were taking antihypertensive or/and lipid-lowering medications were excluded. Finally, the healthy screening data of 206 341 Chinese adults were used to validate the mediating role of intermediate traits between triglyceride and BP identified by MR analysis (Table S2).…”

Section: Data Sourcesmentioning

confidence: 99%

Potential Mediators of Causal Associations of Circulating Triglycerides With Blood Pressure: Evidence From Genetic and Observational Data

Liu

et al. 2022

Hypertension

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Background: Existing evidence indicates that elevated triglycerides may affect blood pressure, but the underlying mechanisms are not fully understood. Herein, we aim to identify the intermediaries of associations of triglyceride with systolic blood pressure and diastolic blood pressure using the Mendelian randomization (MR) framework. Methods: Triglyceride-associated single nucleotide polymorphisms were extracted and used to match phenotypes in PhenoScanner. From the broad spectrum of possible triglyceride-associated traits, potential mediators linking triglyceride to blood pressure were screened out by MR and MR-based mediation analysis. Moreover, cross-sectional observational data of 206 341 adults were used to validate the mediators identified at the genetic level. Results: Among the nearly 100 raw phenotypes matched by 313 triglyceride-associated single nucleotide polymorphisms, 39 traits were filtered and integrated into subsequent analysis. By further filtering using MR analysis, only pulse rate and lymphocyte count (LC) were identified as independent mediators. MR-based mediation analysis showed that genetically predicted LC could mediate 9.2% of the association of triglyceride with systolic blood pressure; genetically predicted pulse rate and LC could mediate 18.3% and 17.6% of the association of triglyceride with DBP, respectively. Observational data also support the mediating role of pulse rate and LC. Conclusions: The current findings highlighted the mediating role of pulse rate and LC on the causal pathway from triglyceride to blood pressure and may contribute to a better understanding of the pathogenic mechanism by which high triglyceride affects other cardiometabolic factors.

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Inverted J-Shaped Association of High-Sensitivity C-Reactive Protein with the Levels of Serum Uric Acid: Cross-Sectional and Longitudinal Analyses

Cited by 2 publications

References 6 publications

Hyperuricaemia: prevalence and association with mortality in an elderly Finnish population

Hyperuricaemia: prevalence and association with mortality in an elderly Finnish population

Potential Mediators of Causal Associations of Circulating Triglycerides With Blood Pressure: Evidence From Genetic and Observational Data

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