Inverted Papilloma: A Review of 53 Cases

Thorp, M. A.; Oyarzabal-Amigo, M F; Plessis, J H du; Sellars, S. L.

doi:10.1097/00005537-200108000-00016

Cited by 53 publications

(42 citation statements)

References 33 publications

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“…The incidence of malignant alteration in the present study was 6.9% (5/72). This result also correlates with findings of some recent series, ranging from 6% (3/53) [68], 8.8% (3/ 34) [69], to 9% (8/89) [10]. So as to avoid a possible influence of different methodologies of HPV detection, we have summarized 16 studies in which PCR was used in order to try to obtain reliable information of HPV infection in IPsSCC [22, 23, 28-31, 33, 36, 38, 40, 42, 44, 70-72].…”

Section: Discussionsupporting

confidence: 93%

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

et al. 2011

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Inverted papillomas (IPs) are the most frequent type of sinonasal papillomas. These benign but destructive lesions are known for their high recurrence rate, probably due to incomplete excision. Our aim was to investigate the frequency of human papillomavirus (HPV) infection in patients with IPs and in IPs associated with squamous cell carcinoma (IPsSCC) and to compare it with the frequency of HPV infections in the control group. The influence of HPV infection on the malignant alteration and recurrence rate of IPs was also evaluated. Paraffin-embedded tissue samples from 68 patients with sinonasal IPs and 5 patients with IPsSCC were analyzed in this retrospective study. The control group consisted of 47 patients who had undergone septoplasty or mucotomy of the inferior turbinate. PCR amplification with consensus primer sets was performed to detect alpha-HPVs, and direct sequencing of the PCR products with the same primers was used to determine the HPV genotypes in the samples. We detected HPV DNA in 20 (30.3%) patients with IPs, in 3 (60%) patients with IPsSCC, and in 6 (13%) patients from the control group. The frequency of HPV infection in the study group was statistically significantly higher (p = 0.032) than in the control group. The presence of HPV DNA was not a statistically significant predictor of the recurrence of IPs (p = 0.745) nor was it a statistically significant risk factor for associated SCC (p = 0.32). Since HPV type 11 was the predominant genotype in the IPs, IPsSCC, and in the control cases, we presume that HPV infection may represent incidental colonization rather than being an important etiological factor of IPs.

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Section: Discussionsupporting

confidence: 93%

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

et al. 2011

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“…3 Several associations between inverted papilloma and SCC have been reported, including (1) synchronous SCC within an inverted papilloma, (2) focal areas of carcinoma in situ within an inverted papilloma, (3) areas of inverted papilloma inside an SCC, (4) metachronous SCC not associated with the original site of the inverted papilloma, and (5) metachronous SCC at the original site of the inverted papilloma, otherwise known as malignant transformation. 20,23 Benninger et al 24 described SCC as being a synchronous lesion in most cases. It is therefore extremely important to evaluate the entire specimen for possible malignant associations.…”

Section: Discussionmentioning

confidence: 99%

Tailored endoscopic surgery for the treatment of sinonasal inverted papilloma

Lee

Huang

2004

Head & Neck

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“…Facial pain, hyposmia, anosmia, and epiphora were rarely encountered. The most frequent symptom of nasal obstruction, was observed in 80 to 98% of the patients (12,13). In patients with simultaneous association of IP and malignancy, epistaxis was the most common symptom (12).…”

Section: Current Advances In the Basic Research And Clinical Managemementioning

confidence: 99%

“…However, some authors also observed patients with a history of symptoms of up to 5 years with no obvious progression of tumor growth (13,14).…”

Section: Current Advances In the Basic Research And Clinical Managemementioning

confidence: 99%

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sauter

Matharu²,

Hörmann³

et al. 2007

Oncol Rep

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Abstract. Inverted papilloma (IP) is a benign sinonasal lesion that has a known propensity for recurrence, local aggressiveness and an association with transformation to squamous cell carcinoma. Due to the high rate of recurrence, association with malignancy and a tendency of multicentricity, the surgical approaches to treatment are controversial. Over the years there has been a slow evolution from aggressive (en bloc) resection by lateral rhinotomy to endoscopic techniques. This progress corresponds to the advances that have been made in endoscopic sinus surgery over the past 15 years. Technological advances have allowed the detection of sinonasal IP before its extension beyond the sinonasal region, thus enabling minimally invasive techniques to be used in the treatment of selected cases of IP. Differences in recurrence rates were not observed for endoscopic management as compared with lateral rhinotomy or sublabial degloving approaches. In terms of aetiology there is certain evidence that the presence of HPV in IP could be predictive of malignant transformation. Although IPs are monoclonal proliferations, they do not fit the profile of a prototypic precursor lesion. In contrast, an increased EGFR and TGF-· expression is associated with early events in IP carcinogenesis. Parameters such as hyperkeratosis, squamous epithelial hyperplasia and a high mitotic index are negative prognostic indicators, which could be useful in the future follow-up of patients with IP. Present literature should encourage us to recommend the use of a uniformly accepted staging system. The propensity for delayed recurrences and the maximal 13% incidence of malignant transformation mandates careful, long-term follow-up.

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Inverted Papilloma: A Review of 53 Cases

Abstract: Aggressive initial management remains the therapeutic aim in this condition.

Cited by 53 publications

References 33 publications

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

Tailored endoscopic surgery for the treatment of sinonasal inverted papilloma

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

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