Inverted Papilloma and Squamous Carcinoma: An Unusual Case

Fechner, Robert E.; Alford, Donald O.

doi:10.1001/archotol.1968.00770010509010

Cited by 50 publications

(12 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ringertz13 considered wcoVi\ plete removal as a prime factor for rec rence frequency. Others have proposed predisposition of the mucosa to papilloma sis as an explanation for recurrence rate 18. of our 29 patients there was at least or ecurrence, and several of these 18 baa merous recurrences, the highest numbe recurrences in an individual patientn ine.…”

mentioning

confidence: 50%

See 1 more Smart Citation

Inverted Papillomas of the Nose and Paranasal Sinuses

Cummings¹,

Goodman²

1970

Archives of Otolaryngology - Head and Neck Surgery

View full text Add to dashboard Cite

mentioning

confidence: 50%

“…[12][13][14][15][16][17][18][19][20][21][22][23] The goal of therapy is to limit the grt endency for recurrence. The propensity »' recurrence is one of the outstanding featm* of the inverted papilloma and is mentions by all authors.…”

mentioning

confidence: 99%

Inverted Papillomas of the Nose and Paranasal Sinuses

Cummings¹,

Goodman²

1970

Archives of Otolaryngology - Head and Neck Surgery

View full text Add to dashboard Cite

“…Data from the largest studies (7,11,33) and recent accurate reviews of the literature (15,34) indicate that the two diseases are concomitantly diagnosed in 3 to 13% of the patients. A further 1 to 1.5% of patients have been shown to present a metachronous malignant lesion (35,36).The development of carcinoma at the site of a previously removed IP is a less common event. In the malignant areas of IP the squamous epithelium shows marked atypia, an increased nuclear to cytoplasmic ratio, conspicuous nucleoli, atypical mitosis in the middle and upper layers, a loss of polarity and dyskeratotic cells.…”

Section: Histopathologymentioning

confidence: 99%

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sauter

Matharu²,

Hörmann³

et al. 2007

Oncol Rep

View full text Add to dashboard Cite

Abstract. Inverted papilloma (IP) is a benign sinonasal lesion that has a known propensity for recurrence, local aggressiveness and an association with transformation to squamous cell carcinoma. Due to the high rate of recurrence, association with malignancy and a tendency of multicentricity, the surgical approaches to treatment are controversial. Over the years there has been a slow evolution from aggressive (en bloc) resection by lateral rhinotomy to endoscopic techniques. This progress corresponds to the advances that have been made in endoscopic sinus surgery over the past 15 years. Technological advances have allowed the detection of sinonasal IP before its extension beyond the sinonasal region, thus enabling minimally invasive techniques to be used in the treatment of selected cases of IP. Differences in recurrence rates were not observed for endoscopic management as compared with lateral rhinotomy or sublabial degloving approaches. In terms of aetiology there is certain evidence that the presence of HPV in IP could be predictive of malignant transformation. Although IPs are monoclonal proliferations, they do not fit the profile of a prototypic precursor lesion. In contrast, an increased EGFR and TGF-· expression is associated with early events in IP carcinogenesis. Parameters such as hyperkeratosis, squamous epithelial hyperplasia and a high mitotic index are negative prognostic indicators, which could be useful in the future follow-up of patients with IP. Present literature should encourage us to recommend the use of a uniformly accepted staging system. The propensity for delayed recurrences and the maximal 13% incidence of malignant transformation mandates careful, long-term follow-up.

show abstract

“…Ringertz (1938) recognized the characteristic endophytic growth pattern and coined the term 'inverting papilloma'. Synonyms for the same entity were 'genuine papilloma of the nasal cavity' (Kramer and Som, 1935), 'inverting papilloma' (Norris, 1963), and 'inverted papilloma' (Fechner and Alford, 1968;Hyams, 1971). Berendes (1966) noted the tendency towards destructive growth, recurrence, and epithelial metaplasia and named it 'malignant papilloma'.…”

mentioning

confidence: 99%