2020
DOI: 10.1002/path.5390
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Inverted urothelial papilloma and urothelial carcinoma with inverted growth are histologically and molecularly distinct entities

Abstract: Inverted urothelial papilloma and urothelial carcinoma with inverted growth are histologically and molecularly distinct entities We read with great interest the invited commentary by Akgul et al [1] on our report on the genomic landscape of urothelial papilloma (UP) and inverted urothelial papilloma (IUP) published in a recent issue of The Journal of Pathology [2]. The authors highlighted the salient findings of our study, namely that IUP and UP have genomic profiles that are distinct from urothelial carcinoma… Show more

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Cited by 9 publications
(11 citation statements)
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“…Differential diagnosis of IUP and PUC with inverted growth is one of the common pitfalls in pathological diagnosis of bladder neoplasms due to the morphologic similarity ( 3 , 11 , 12 ). We aimed to resolve this challenge by validating SERPINH1 and PYGB using immunohistochemistry in IUPs and PUCs with inverted growth.…”
Section: Resultsmentioning
confidence: 99%
“…Differential diagnosis of IUP and PUC with inverted growth is one of the common pitfalls in pathological diagnosis of bladder neoplasms due to the morphologic similarity ( 3 , 11 , 12 ). We aimed to resolve this challenge by validating SERPINH1 and PYGB using immunohistochemistry in IUPs and PUCs with inverted growth.…”
Section: Resultsmentioning
confidence: 99%
“…Several molecular studies have been performed in IUP [ 11 , 12 ]. Interestingly, IUP share with UP the RAS pathway activation in its genesis without FGFR3 , TERT , TP53 , or RB1 gene implications, otherwise typical in urothelial carcinomas [ 13 , 14 ].…”
Section: Inverted Urothelial Papilloma (Iup)mentioning
confidence: 99%
“…Conversely, HRAS mutations have been reported in inverted tumors [18], along with mutations in other members of the RAS pathway, namely mutations encoding the KRAS G12R and BRAF G469A mutants in LG-UC-IGP and HG-UC-IGP cases, respectively [18]. Moreover, an oncogenic HRAS or KRAS missense mutation was present in nearly all cases of IP and urothelial papilloma according to a recent series [38][39][40], compared to two of 25 UC-IGP cases (8%). In both cases, further oncogenic mutations in chromatin-modifying genes and/or cell cycle regulators were present.…”
Section: Ras Genesmentioning
confidence: 99%
“…Interestingly, the same C228T mutation was found in inverted lesions as well as in the majority of conventional UC, suggesting that a subset of IP might share a molecular pathway of carcinogenesis with UC-IGP and conventional UC [ 47 ]. Such findings suggest the use of TERT mutation analysis in the differential diagnosis of benign and malignant lesions [ 38 , 40 , 47 - 49 ].…”
Section: Molecular Featuresmentioning
confidence: 99%
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