Apart from food, other important needs in the care of human bodies are cosmetics and drugs. For long the latter two are obtained from chemical formulations and phytochemicals (commonly used in Ethnomedicine), use of bioactive compounds from insects (i.e. “ento medicine” and “ento cosmetics”) is a recent development in research, even though the bioactive compounds were discovered long ago. This chapter is a review on a number of substances extracted from various insect species that are useful in cosmetics, pharmaceutical industries as well as those that form part of prescription for healing in orthodox and traditional medicine. The review is based on information from scientific reports, Google, e-library, textbooks. A number of substances were found to have been incorporated into cosmetic and pharmaceutical products and as part of prescriptions for healing in orthodox medicine, many others at elementary stages of investigation, purification and development. The findings showed that insects have a lot of bioactive substances that need to be harnessed for the good man.