Investigating a Novel Neurodegenerative Disease Toxic Mechanism Involving Lipid Binding Specificity of Amyloid Oligomers
Sarah S. Hirschbeck,
Edward T. Lindberg,
Joshua H. Jang
et al.
Abstract:Exploring the mechanisms underlying the toxicity of amyloid oligomers (AOs) presents a significant opportunity for discovering cures and developing treatments for neurodegenerative diseases. Recently, using a combination of ion mobility spectrometry-mass spectrometry (IMS-MS) and X-ray crystallography (XRC), we showed that the peptide KVKVLWDVIEV, which is the G95W mutant of αB-Crystallin (90−100) and abbreviated as G6W, self-assembles up to a dodecamer that structurally resembles lipid transport proteins. The… Show more
Pregnenolone-based derivatives have been synthesized to inhibit the protofibril formation in order to reduce Aβ1–42 production and prevent its aggregation.
Pregnenolone-based derivatives have been synthesized to inhibit the protofibril formation in order to reduce Aβ1–42 production and prevent its aggregation.
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