Investigating apical adverse effects of four endocrine active substances in the freshwater gastropod Lymnaea stagnalis

Giusti, Arnaud; Lagadic, Laurent; Barsi, Alpar; Thomé, Jean-Pierre; Joaquim-Justo, Célia; Ducrot, Virginie

doi:10.1016/j.scitotenv.2014.05.130

Cited by 27 publications

(23 citation statements)

References 57 publications

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“…CPA and VZ had no significant effect on cumulated oviposition and fertility in adult snails in single chemical treatment approach, however 2 and 10 μg/L CPA as well as 10-240 ng/L VZ treatments induced a significant decrease in egg number per egg mass compared to control. However, in this experiment no clear concentration-response relationship was described [27,106]. CPA, VZ and tributyltin (TBT) were also tested on other three gastropod species, Marisa cornuarietis, Nucella lapillus and Nassarius reticulatus in a chronic experiment.…”

Section: Progestogen Effects In L Stagnalismentioning

confidence: 91%

“…The vinclozolin (VZ) is mainly known as anti-androgen, which can also bind to estrogen and progestogen receptors in vertebrates. Using these progestogens, Ducrot and Giusti published no significant difference in shell length of adult L. stagnalis between control and treated groups after 21 days of exposure to any of the tested chemicals [25,27]. However, Ducrot observed slower growing among juveniles, sub-adults and young adults exposed to the highest concentration of VZ (2500 μg/L) during the first week, but partly recovered during the second and third weeks, so that growth pattern did not lead to a significant decrease in the mean shell size compared to control group.…”

Section: Progestogen Effects In L Stagnalismentioning

confidence: 99%

“…Egg quality showed no significant difference in CPA and VZ treatments, however polyembryony was the most frequent phenomena. A 3-week long CPA treatment resulted in significant increase of the frequency of polyembryony in concentration dependent manner from 2 μg/L concentration [27]. In addition, the whole egg mass quality was also assessed in progestogen mixture treatment of adult snails with a three-graded scheme, which integrates the number of polyembryonic eggs with eggs containing dead zygotes.…”

Section: Progestogen Effects In L Stagnalismentioning

confidence: 99%

See 2 more Smart Citations

Pond Snail Reproduction as Model in the Environmental Risk Assessment: Reality and Doubts

Pirger¹,

Zrínyi²,

Maász³

et al. 2018

Biological Resources of Water

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In European limnetic systems, the most relevant endocrine-disrupting chemicals (EDCs) of steroid type are the natural and synthetic hormones, phytosterols, pesticides, biocides and other chemicals produced by the plastic industry. Their presence in aquatic ecosystems represents a potentially adverse environmental and public health impact. Furthermore, this is a warning signal that the current handling of pharmaceuticals needs to be further improved. Nowadays, it has become clear that EDCs have specific disturbing effects on the neuroendocrine system of invertebrate and vertebrate aquatic animals, particularly gastropods. Among a latter, pond snail (Lymnaea stagnalis) has been used as the first aquatic non-arthropod test organism in studying the effect of EDCs because they are sensitive to various anthropogenic steroids, like progestogens. Investigating a variety of reproductive endpoints of Lymnaea, such as fecundity, oocyte production, egg mass production, the quality of egg masses, the shell size in development and after egg-laying, the time window of cell division in the offspring, the metabolite content of single-cell zygotes and egg albumen has concluded that progestogen contaminations in water are detrimental for reproduction and early stage development of Lymnaea. This chapter is an attempt to show whether Lymnaea reproduction, despite many altering reproductive endpoints, is a suitable model for environmental risk assessment or not.

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Section: Progestogen Effects In L Stagnalismentioning

confidence: 91%

Section: Progestogen Effects In L Stagnalismentioning

confidence: 99%

Section: Progestogen Effects In L Stagnalismentioning

confidence: 99%

See 1 more Smart Citation

Pond Snail Reproduction as Model in the Environmental Risk Assessment: Reality and Doubts

Pirger¹,

Zrínyi²,

Maász³

et al. 2018

Biological Resources of Water

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“…Saúde Pública, Rio de Janeiro, 32(3):e00056715, mar, 2016 Adult males and females Reproductive changes 77 …”

Section: Sida Crystallinamentioning

confidence: 99%

Regulamentação do estrogênio sintético 17α-etinilestradiol em matrizes aquáticas na Europa, Estados Unidos e Brasil

et al. 2016

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O estrogênio sintético 17α-etinilestradiol, principal componente utilizado em formulações de contraceptivos orais, tem sido apontado como um dos principais compostos responsáveis por provocar efeitos adversos no sistema endócrino de várias espécies. O objetivo deste estudo foi analisar o estado da arte dos dispositivos legais e normativos referentes ao controle desse estrogênio sintético nas águas da Europa e dos Estados Unidos, e traçar um paralelo com a realidade brasileira. No geral, os países têm buscado ampliar a regulamentação e monitoramento de alguns micropoluentes emergentes que antes não eram objeto de atenção por parte dos dispositivos legais. A Europa está mais avançada no que tange à qualidade dos corpos hídricos, enquanto que nos Estados Unidos esta substância é alvo de regulamentação apenas para a água destinada ao consumo humano. No Brasil, ainda não há nenhum dispositivo legal ou normativo que aborde esse estrogênio, o que pode ser associado a uma baixa maturidade do sistema brasileiro quanto ao controle de poluentes hídricos.

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“…Nevertheless, Gaume et al (2014) highlighted that a CLD exposure caused the induction of genes involved in the anti-oxidative defense (e.g., catalase and glutathione peroxidase) or in the biotransformation process (i.e., cytochrome P450 and glutathione-S-transferase). Giusti et al (2014) showed the reduction of the oviposition and the fecundity of the gastropod Lymnaea stagnalis exposed to CLD at environmental relevant concentrations. Finally, our previous study showed that CLD exposure in laboratory affected the 20-hydroxyecdysone concentration (i.e., molting hormone) and the chitobiase activity (i.e., molting enzyme), both controlled by the endocrine system, in the decapod Macrobrachium rosenbergii, suggesting that CLD could be an EDC in invertebrates (Lafontaine et al 2016).…”

Section: Introductionmentioning

confidence: 98%

Vitellogenin and vitellogenin receptor gene expression and 20-hydroxyecdysone concentration in Macrobrachium rosenbergii exposed to chlordecone

Lafontaine

Hanikenne

Boulangé-Lecomte

et al. 2016

Environ Sci Pollut Res

Self Cite

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Chlordecone is a persistent organochlorine pesticide widely used in Guadeloupe (French West Indies) to control the banana weevil Cosmopolites sordidus. Although it was previously highlighted that chlordecone may affect the reproduction and growth of vertebrate species, little information is available on the chlordecone effects in invertebrates. The present study investigated the effects of chlordecone on a hormone and a protein having key roles in reproduction and growth of the decapod crustacean Macrobrachium rosenbergii, by measuring the 20-hydroxyecdysone concentration, vitellogenin, and vitellogenin receptor gene expression, as well as the bioconcentration of chlordecone in exposed prawns. First, the results revealed that chlordecone was accumulated in M. rosenbergii. Then, it was found that Vg and VgR gene expression were increased in male and female M. rosenbergii exposed to chlordecone for 90 and 240 days, while the 20-hydroxyecdysone concentrations were decreased. This work suggests that chlordecone accumulates in prawn tissues and could affect key molecules involved in the reproduction and the growth of the invertebrate M. rosenbergii. However, many questions remain unresolved regarding the impacts of chlordecone on growth and reproduction and the signaling pathways responsible for these effects, as well as the potential role of confounding factors present in in situ studies.

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Investigating apical adverse effects of four endocrine active substances in the freshwater gastropod Lymnaea stagnalis

Cited by 27 publications

References 57 publications

Pond Snail Reproduction as Model in the Environmental Risk Assessment: Reality and Doubts

Pond Snail Reproduction as Model in the Environmental Risk Assessment: Reality and Doubts

Regulamentação do estrogênio sintético 17α-etinilestradiol em matrizes aquáticas na Europa, Estados Unidos e Brasil

Vitellogenin and vitellogenin receptor gene expression and 20-hydroxyecdysone concentration in Macrobrachium rosenbergii exposed to chlordecone

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