Investigating causal relationships between the gut microbiota and allergic diseases: A mendelian randomization study

Wang, Yiwei; Liu, Tian; Wan, Zhongmin; Wang, Lin; Hou, Jianbo; Shi, Mai; Tsui, Stephen Kwok Wing

doi:10.3389/fgene.2023.1153847

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…In a previous MR analysis, families Bifidobacteriaceae and Clostridiaceae, and genera Bifidobacterium and Anaerostipes were found to be associated with an increased risk of AR. However, due to limited number of SNPs and sample size, the causal associations could not be replicated in two similar outcome studies (Wang et al, 2023). Our study possesses several strengths.…”

Section: Discussionmentioning

confidence: 91%

Genetic associations between gut microbiota and allergic rhinitis: an LDSC and MR analysis

Zheng,

Chen,

Zhuang

et al. 2024

Front. Microbiol.

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BackgroundSeveral studies have suggested a potential link between allergic rhinitis (AR) and gut microbiota. In response, we conducted a meta-analysis of Linkage Disequilibrium Score Regression (LDSC) and Mendelian randomization (MR) to detect their genetic associations.MethodsSummary statistics for 211 gut microbiota taxa were gathered from the MiBioGen study, while data for AR were sourced from the Pan-UKB, the FinnGen, and the Genetic Epidemiology Research on Aging (GERA). The genetic correlation between gut microbiota and AR was assessed using LDSC. The principal estimate of causality was determined using the Inverse-Variance Weighted (IVW) method. To assess the robustness of these findings, sensitivity analyses were conducted employing methods such as the weighted median, MR-Egger, and MR-PRESSO. The summary effect estimates of LDSC, forward MR and reverse MR were combined using meta-analysis for AR from different data resources.ResultsOur study indicated a significant genetic correlation between genus Sellimonas (Rg = −0.64, p = 3.64 × 10−5, Adjust_P = 3.64 × 10−5) and AR, and a suggestive genetic correlation between seven bacterial taxa and AR. Moreover, the forward MR analysis identified genus Gordonibacter, genus Coprococcus2, genus LachnospiraceaeUCG010, genus Methanobrevibacter, and family Victivallaceae as being suggestively associated with an increased risk of AR. The reverse MR analysis indicated that AR was suggestively linked to an increased risk for genus Coprococcus2 and genus RuminococcaceaeUCG011.ConclusionOur findings indicate a causal relationship between specific gut microbiomes and AR. This enhances our understanding of the gut microbiota’s contribution to the pathophysiology of AR and lays the groundwork for innovative approaches and theoretical models for future prevention and treatment strategies in this patient population.

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Section: Discussionmentioning

confidence: 91%

Genetic associations between gut microbiota and allergic rhinitis: an LDSC and MR analysis

Zheng,

Chen,

Zhuang

et al. 2024

Front. Microbiol.

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“…The former can initiate blood coagulation (plasma-free clotting) [ 50 ], whereas the latter can cleave substance P and chemokines [ 51 ]. The bulk of the human microbiota inhabits the gastrointestinal tract (GIT), where it modulates diverse aspects such as insulin signaling, behavior, and allergy [ 52 , 53 , 54 , 55 ]. Similar to EVs that play a role in the host’s intercellular communication, microbiota release outer membrane vesicles (OMVs) that play a role in host–microbiota communication [ 56 ].…”

Section: Biology Of Extracellular Vesiclesmentioning

confidence: 99%

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

Al-Jipouri,

Eritja,

Bozic

2023

IJMS

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Extracellular vesicles (EVs) are nanoparticles released from various cell types that have emerged as powerful new therapeutic option for a variety of diseases. EVs are involved in the transmission of biological signals between cells and in the regulation of a variety of biological processes, highlighting them as potential novel targets/platforms for therapeutics intervention and/or delivery. Therefore, it is necessary to investigate new aspects of EVs’ biogenesis, biodistribution, metabolism, and excretion as well as safety/compatibility of both unmodified and engineered EVs upon administration in different pharmaceutical dosage forms and delivery systems. In this review, we summarize the current knowledge of essential physiological and pathological roles of EVs in different organs and organ systems. We provide an overview regarding application of EVs as therapeutic targets, therapeutics, and drug delivery platforms. We also explore various approaches implemented over the years to improve the dosage of specific EV products for different administration routes.

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TSP50 Attenuates DSS‐Induced Colitis by Regulating TGF‐β Signaling Mediated Maintenance of Intestinal Mucosal Barrier Integrity

Li,

Niu,

et al. 2024

Advanced Science

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The integrity of the intestinal mucosal barrier is crucial for protecting the intestinal epithelium against invasion by commensal bacteria and pathogens, thereby combating colitis. The investigation revealed that the absence of TSP50 compromised the integrity of the intestinal mucosal barrier in murine subjects. This disruption facilitated direct contact between intestinal bacteria and the intestinal epithelium, thereby increasing susceptibility to colitis. Mechanistic analysis indicated that TSP50 deficiency in intestinal stem cells (ISCs) triggered aberrant activation of the TGF‐β signaling pathway and impeded the differentiation of goblet cells in mice, leading to impairment of mucosal permeability. By inhibiting the TGF‐β pathway, the functionality of the intestinal mucosal barrier is successfully restored and mitigated colitis in TSP50‐deficient mice. In conclusion, TSP50 played a crucial role in maintaining the intestinal mucosal barrier function and exhibited the preventive effect against the development of colitis by regulating the TGF‐β signaling pathway.

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Investigating causal relationships between the gut microbiota and allergic diseases: A mendelian randomization study

Cited by 3 publications

References 31 publications

Genetic associations between gut microbiota and allergic rhinitis: an LDSC and MR analysis

Genetic associations between gut microbiota and allergic rhinitis: an LDSC and MR analysis

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

TSP50 Attenuates DSS‐Induced Colitis by Regulating TGF‐β Signaling Mediated Maintenance of Intestinal Mucosal Barrier Integrity

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