2017
DOI: 10.1101/107375
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Investigating circadian rhythmicity in pain sensitivity using a neural circuit model for spinal cord processing of pain

Abstract: Primary processing of painful stimulation occurs in the dorsal horn of the spinal cord. In this article, we introduce mathematical models of the neural circuitry in the dorsal horn responsible for processing nerve fiber inputs from noxious stimulation of peripheral tissues and generating the resultant pain signal. The differential equation models describe the average firing rates of excitatory and inhibitory interneuron populations, as well as the wide dynamic range (WDR) neurons whose output correlates with t… Show more

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Cited by 2 publications
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References 39 publications
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