Investigating current practices in renal function measurement and carboplatin dosing in children with cancer – a UK perspective

Roberts, Eve; Mogg, Jasper; Barnfield, Mark C.; Veal, Gareth J.

doi:10.1080/08880018.2020.1713939

Cited by 1 publication

(2 citation statements)

References 14 publications

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“…The unadjusted GFR (uGFR) reflects the underlying GFR (ml/min) and nephron mass of the donor kidney, independent of body size and therefore permits an accurate determination of the relative amount of GFR recovery in a pediatric recipient of an adult‐sized kidney. This approach using uGFR has been applied when size adjustment is undesirable for test validation purposes 40–43 or is problematic due to irregular patient size in some populations 44–47 …”

Section: Methodsmentioning

confidence: 99%

“…This approach using uGFR has been applied when size adjustment is undesirable for test validation purposes [40][41][42][43] or is problematic due to irregular patient size in some populations. [44][45][46][47] The donor and recipient BSA, respectively, can be used to estimate uGFR from eGFR in each, as follows: AKI recovery associated with SGF was investigated using two indicators:…”

Section: Sgf Indicators Of Post-transplant Aki Recoverymentioning

confidence: 99%

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Clinical indicators of slow graft function and outcome after pediatric kidney transplantation

Bajaj

Gershony

Afshar

et al. 2022

Pediatric Transplantation

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Background Lesser degrees of perioperative ischemia–reperfusion injury that does not require dialysis may nonetheless influence allograft outcomes, necessitating evaluation of suitable surrogate indicators of perioperative allograft injury. Methods This retrospective analysis of pediatric kidney transplants evaluated two indicators representing pace and completeness of recovery, for association with 12‐month estimated glomerular filtration rate (eGFR) and first‐year rate of eGFR decline: time to creatinine nadir (TTN) and ratio of recipient/donor unadjusted GFR (uGFRR/D) at 1‐month post‐transplant. Donor, recipient, and perioperative risk factors were tested further for association with these 2 indicators. Results 179 patients (190 transplants) aged 13 (IQR 7–17) years and 56% male were included. Twelve‐month eGFR was strongly associated with unadjusted GFR at 1 month (uGFR1M, p < .001) and uGFRR/D (p = .003), but not with TTN. None of the indicators was associated with the rate of subsequent eGFR decline after 1‐month post‐transplant. As a potential surrogate indicator, uGFR1M is effectively modeled by TTN and uGFRR/D (adjusted R2 = 0.57) and is associated with 12‐month eGFR (β = 0.81 ± 0.08; p < .001). Clinical factors associated with uGFRR/D included donor uGFR (p < .001), BSA (p = .026), age (p = .074), and recipient BSA (p < .001). Factors associated with pace of recovery (TTN) included donor uGFR (p = .018), type (p = .019), and recipient BSA (p = .022). Conclusions The uGFRR/D ratio, but not TTN, is a useful indicator of perioperative allograft damage that is associated with one‐year functional outcome; and uGFR1M is a potential early surrogate outcome. Donor, recipient, and perioperative factors that are associated with slow allograft function are identified.

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Section: Methodsmentioning

confidence: 99%