Investigating differences of medications in hospitalized schizophrenia and schizoaffective disorder patients: impact of substance use

Durmaz, Onur; Büyükçapar, Aslı; Arinci, Berçem; Inceman, Can; Kumsar, Neslihan Akkişi

doi:10.1080/14659891.2022.2077249

Cited by 1 publication

(1 citation statement)

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“…Such a significant decrease was not observed for the LAI + Oral group, which may be related to the clinicians’ preference of prescribing LAIs to real-world patients with more severe illness that are often complicated with comorbidities. Interestingly, our findings indicated that all patients who were prescribed LAIs also received oral antipsychotic prescriptions, which was corroborated in previous studies conducted on patient populations with a diagnosis of SSD Turkiye (Üçok et al , 2021; Durmaz et al , 2022). This appears to be prevalent among Turkish clinicians, possibly due to their cautious approach to ensure sufficient exposure to antipsychotics, especially in cases of severe psychopathology or violent history.…”

Section: Discussionsupporting

confidence: 90%

Treatment adherence in forensic patients with schizophrenia spectrum disorders discharged on long-acting injectable antipsychotics: a comparative 3-year mirror-image study

Balcioglu,

Ozdemir,

Oncu

et al. 2023

International Clinical Psychopharmacology

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In this retrospective 3-year mirror-image study, 81 patients with schizophrenia spectrum disorders (SSD) were categorized according to whether they were prescribed long-acting injectable antipsychotics (LAI) or not upon discharge from the inpatient forensic psychiatric unit. Antipsychotic adherence, which was staged based on the ‘proportion of days covered’ method, as well as other clinical outcomes was compared between pre- and post-index mirror periods. In both Oral-only (n = 46) and Oral + LAI (n = 35) groups, the number of hospitalizations, convictions and months spent in the hospital were significantly lower in the post-index period than the pre-index period. Differences in these three variables between pre- and post-index periods were NS between the two groups. A mixed effect ordinal logistic regression model with random intercept showed that the odds ratio of obtaining a higher treatment adherence score in the post-index period was more pronounced in the Oral + LAI group than in the Oral-only group, considering adherence at baseline and the length of stay during the index hospitalization as potential confounders. Discharge with LAIs in a forensic psychiatric cohort of SSD was associated with a greater mid- to long-term improvement in antipsychotic medication adherence compared to discharge with oral-only antipsychotics.

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Section: Discussionsupporting

confidence: 90%