2023
DOI: 10.1371/journal.pone.0276246
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Investigating discriminating concentrations for monitoring susceptibility to broflanilide and cross resistance to other insecticide classes in Anopheles gambiae sensu lato, using the new WHO bottle bioassay method

Abstract: Background Broflanilide is a new insecticide being developed for malaria vector control. As new insecticide chemistries become available, strategies to preserve the susceptibility of local malaria vectors and extend their useful life need to be considered before large scale deployment. This requires the development of appropriate testing procedures and identification of suitable discriminating concentrations for monitoring susceptibility in wild vector populations to facilitate decision making by control progr… Show more

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Cited by 12 publications
(1 citation statement)
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“…World Health Organization (WHO) bottle bioassays were used to assess the susceptibility of mosquitoes from each village to clothianidin and bro anilide. Clothianidin was tested at a discriminating concentration of 90µg/bottle provided by the manufacturer while bro anilide was tested at 6µg/bottle determined in preliminary dose-response bioassays [40]. To prevent crystallization of the insecticide in bottle bioassays and to improve bioavailability and uptake by exposed mosquitoes, Mero® (81% rapeseed oil methyl ester; Bayer CropScience) was used as an adjuvant at a dose of 500ppm for bro anilide and 1000ppm for clothianidin.…”
Section: Insecticide Susceptibility Monitoringmentioning
confidence: 99%
“…World Health Organization (WHO) bottle bioassays were used to assess the susceptibility of mosquitoes from each village to clothianidin and bro anilide. Clothianidin was tested at a discriminating concentration of 90µg/bottle provided by the manufacturer while bro anilide was tested at 6µg/bottle determined in preliminary dose-response bioassays [40]. To prevent crystallization of the insecticide in bottle bioassays and to improve bioavailability and uptake by exposed mosquitoes, Mero® (81% rapeseed oil methyl ester; Bayer CropScience) was used as an adjuvant at a dose of 500ppm for bro anilide and 1000ppm for clothianidin.…”
Section: Insecticide Susceptibility Monitoringmentioning
confidence: 99%