Investigating extradomiciliary transmission of tuberculosis: An exploratory approach using social network patterns of TB cases and controls and the genotyping of Mycobacterium tuberculosis

Assessing a transmission network of Mycobacterium tuberculosis in an African city using single nucleotide polymorphism threshold analysis

“…More recent epidemiological studies show that M. tuberculosis transmission is more likely to occur outside of the household (Buu et al, 2010;Yates et al, 2016). From outbreak investigations, research shows that transmission of M. tuberculosis bacilli can occur in social settings (Auld et al, 2018;Pinho et al, 2020) and at other events in the community (Cavalcante et al, 2010;Verver et al, 2004) with the actual frequency of occurrence in these settings outside of the household not being known. Thus, a more robust understanding of the transmission process would help to identify infected individuals early in the disease course, thus preventing transmission and subsequent disease (Meertens et al, 2013).…”