Investigating gradient sensing in cells through optical micromanipulation

Losert, Wolfgang; Poole, Cory; Skupsky, Ron

doi:10.1117/12.589648

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…such that their corresponding functions can be investigated (Greulich, 1999). Moreover, rapid and precise transportation of cells can benefit the fabrication of pharmacophoreerythrocyte complexes (Grover et al, 2001), cell-cell interactions (Losert et al, 2005), and cell fusion, etc.…”

Section: Introductionmentioning

confidence: 99%

Automatic transportation of biological cells with a robot-tweezer manipulation system

Sun

2011

The International Journal of Robotics Research

169

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The positioning of biological cells has become increasingly important in biomedical research such as drug discovery, cell-to-cell interaction, and tissue engineering. Significant demand for both accuracy and productivity in cell manipulation highlights the need for automated cell transportation with integrated robotics and micro/nano-manipulation technologies. Optical tweezers, which use highly focused low-power laser beams to trap and manipulate particles at the micro/nanoscale, can be treated as special robot ‘end-effectors’ to manipulate biological objects in a noninvasive way. In this paper, we propose to use a robot-tweezer manipulation system for automatic transportation of biological cells. A dynamics equation of the cell in an optical trap is analyzed. Closed-loop controllers are designed for positioning single cells as well as multiple cells. A synchronization control technology is utilized for multicell transportation with maintained cell pattern. Experiments are performed on transporting live cells to demonstrate the effectiveness of the proposed approach.

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Section: Introductionmentioning

confidence: 99%

Automatic transportation of biological cells with a robot-tweezer manipulation system

Sun

2011

The International Journal of Robotics Research

169

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“…for investigation of their corresponding functions [26]. Moreover, the rapid and precise transportation of cells can benefit the fabrication of pharmacophore-erythocyte complexes [16], studies on cell communication [27], and cell fusion, etc.…”

Section: Introductionmentioning

confidence: 99%

Dynamics analysis and closed-loop control of biological cells in transportation using robotic manipulation system with optical tweezers

Sun

Feng

2010

2010 IEEE International Conference on Automation Science and Engineering

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Increasing demands for both accuracy and productivity in cell manipulation highlight the need for automated process that integrates robotics and micro manipulation technologies. Optical tweezers, which use low power laser beams to trap and manipulate particles at micro/nano scale, have provided a revolutionary solution to manipulate biological objects in a noninvasive way. In this paper, we propose to use a robot-tweezer manipulation system for automatic manipulation of biological cells. Dynamics equation of the trapped cell during the movement is analyzed. A closed-loop controller is designed for cell transportation. Experiments are performed on the live cells to verify the effectiveness of the proposed approach.

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Cell Manipulation with Robot-Aided Optical Tweezers Technology

Tan

Sun

2012

Selected Topics in Micro/Nano-Robotics for Biomedical Applications

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Investigating gradient sensing in cells through optical micromanipulation

Cited by 3 publications

References 13 publications

Automatic transportation of biological cells with a robot-tweezer manipulation system

Automatic transportation of biological cells with a robot-tweezer manipulation system

Dynamics analysis and closed-loop control of biological cells in transportation using robotic manipulation system with optical tweezers

Cell Manipulation with Robot-Aided Optical Tweezers Technology

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