Investigating in Vitro Drug Release Mechanisms Inside Dosage Forms

Development of a novel method utilising dissolution imaging for the measurement of swelling behaviour in hydrophilic matrices

“…Confocal laser scanning microscopy (CLSM) has also been utilised in a variety of pharmaceutical applications (Pygall et al, 2007). Key related applications include the measurement of the surface roughness of tablets (Peltonen et al, 1997), monitoring gel layer growth and water penetration in hydrophilic matrices (Melia et al, 1997) and surface profilometry of dissolving tablet surfaces (Healy et al, 1995).…”