2024
DOI: 10.1002/ctm2.70113
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Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing

Jingyuan Huo,
Zhen Wang,
Wenting Zhao
et al.

Abstract: BackgroundPrimary cardiac angiosarcoma (PCAS) is a rare and aggressive heart tumour with limited treatment options and a poor prognosis. Understanding cellular heterogeneity and tumour microenvironment (TME) is crucial for the development of effective therapies. Here, we investigated the intratumoural heterogeneity and TME diversity of PCAS using single‐cell RNA sequencing (scRNA‐seq).MethodsWe performed scRNA‐seq analysis on tumour samples from four patients with PCAS, supplemented with multicolour immunohist… Show more

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