Investigating Janus morphology development of poly(acrylic acid)/poly(2‑(dimethylamino)ethyl methacrylate) composite particles: An experimental study and mathematical modeling of DOX release

Fallahi-Samberan, Mehrab; Salami‐Kalajahi, Mehdi; Dehghani, Elham; Abbasi, Farhang

doi:10.1016/j.microc.2018.11.017

Cited by 34 publications

(10 citation statements)

References 48 publications

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“…This suggests that in the absence of a suitable surfactant, the polymerization medium was not able to control the particle size. The results also showed that ionic surfactants were more successful in synthesizing fully spherical and monodispersed particles as was similar to other researches 34 . It is noteworthy to say that number‐average diameter of each sample was calculated using FE‐SEM images via the method described before 35 …”

Section: Resultssupporting

confidence: 83%

“…The results also showed that ionic surfactants were more successful in synthesizing fully spherical and monodispersed particles as was similar to other researches. 34 It is noteworthy to say that number-average diameter of each sample was calculated using FE-SEM images via the method described before. 35 All utilized surfactants have an amphiphilic nature and two-part structure, including a hydrophilic head group and a hydrophobic tail.…”

Section: Instrumentationmentioning

confidence: 99%

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Synthesis of core‐shell and Janus polystyrene@polypyrrole particles by variation of surfactant and monomer amount through seeded emulsion polymerization

Dehghani

Amani

Salami‐Kalajahi

2020

Polymers for Advanced Techs

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Polystyrene (PS) seed particles were synthesized under similar conditions with different anionic, cationic, and non-ionic surfactants, as well as without surfactant. The effect of surfactant type on the morphology and size of PS particles was investigated. These particles were then used as seeds in chemical oxidative polymerization of pyrrole and the effect of surfactant type and pyrrole/seed weight ratio on the morphology of the resulting composite particles was monitored. According to the results, different surface properties of PS seed particles resulted in various morphologies. Anionic surfactant led to formation of core-shell structure because of electrostatic interactions between polypyrrole (PPy) oligomers and seed particles. However, cationic surfactant led to electrostatic repulsions between positively-charged PPy oligomers and PS particles' surface and formation of patchy structures. Non-ionic surfactant resulted in formation of snowman-like Janus particles due to absence of electrostatic interactions. K E Y W O R D S conductive polymers, core-shell particles, Janus particles, polypyrrole 1 | INTRODUCTION π-conjugated polymers which are usually known as semi-conductive polymers, can be electrically conductive due to localization of the π-electrons which means there is no limitation on the movement of electrons in π-conjugated polymers. In summary, a polymer is capable to transport charge when an electron is added or subtracted and it is well known that, it might happen by using oxidation and reduction processes which is generally called "doping". 1,2 It is notable to say that the doping degree and the synthesis method have a great effect on the polymer properties. 3,4 Applications of these materials include field effect transistors, 5 organic light emitting diodes (OLEDs), 6 photovoltaic devices, 7 sensors, 5 solar cells, 8 etc. Semi-conductive polypyrrole (PPy) has attracted considerable attention due to its excellent electrical, electrochemical, and optical properties, environmental stability, etc. 9 These unique characteristics have provided great applicability in lightweighted batteries, 10 electrochemical sensors, 11 optical devices, 12 membrane separation, 13,14 etc. PPy have also found applicability in biomedical fields. 15,16 It has been utilized to produce an electrical stimulus for cell growth in tissue engineering and also regeneration of neuron cells. 17 However, the poor affinity between PPy and cells due to the hydrophobicity of PPy has limited these applications. Despite semi-conductive polymers' excellent electrical performance, π-conjugated chains lead them to have poor solubility, low mechanical properties, and poor processability which hinder their applications in technology. 18 One possible solution to overcome these issues can be preparation of semi-conductive polymer-based composites. These semi-conducting composites help PPy to have better performance in mechanical strength, solubility, processability, etc. 19-21 Among different kind of composite particles, Janus structures have a...

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Section: Resultssupporting

confidence: 83%

Section: Instrumentationmentioning

confidence: 99%

Synthesis of core‐shell and Janus polystyrene@polypyrrole particles by variation of surfactant and monomer amount through seeded emulsion polymerization

Dehghani

Amani

Salami‐Kalajahi

2020

Polymers for Advanced Techs

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“…They have noted that the mechanism of DOX release is anomalous or mixed between Fickian diffusion and relaxation transport. M. Fallahi-Samberan et al [ 46 , 47 ] investigated the kinetics of DOX release from composite particles by different mathematical models. They have found that the kinetics release of DOX was well described by the Korsmeyer–Peppas model, which means that the controlling factor in the release process was a polymeric matrix.…”

Section: Resultsmentioning

confidence: 99%

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

Chudoba

Jażdżewska

Łudzik

et al. 2021

IJMS

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The article discusses the release process of doxorubicin hydrochloride (DOX) from multi-wall carbon nanotubes (MWCNTs). The studies described a probable mechanism of release and actions between the surface of functionalized MWCNTs and anticancer drugs. The surface of carbon nanotubes (CNTs) has been modified via treatment in nitric acid to optimize the adsorption and release process. The modification efficiency and physicochemical properties of the MWCNTs+DOX system were analyzed by using SEM, TEM, EDS, FTIR, Raman Spectroscopy and UV-Vis methods. Based on computer simulations at pH 7.4 and the experiment at pH 5.4, the kinetics and the mechanism of DOX release from MWNT were discussed. It has been experimentally observed that the acidic pH (5.4) is appropriate for the efficient release of the drug from CNTs. It was noted that under acidic pH conditions, which is typical for the tumour microenvironment almost 90% of the drug was released in a relatively short time. The kinetics models based on different mathematical functions were used to describe the release mechanism of drugs from MWCNTs. Our studies indicated that the best fit of experimental kinetic curves of release has been observed for the Power-law model and the fitted parameters suggest that the drug release mechanism of DOX from MWCNTs is controlled by Fickian diffusion. Molecular dynamics simulations, on the other hand, have shown that in a neutral pH solution, which is close to the blood pH, the release process does not occur keeping the aggregation level constant. The presented studies have shown that MWCNTs are promising carriers of anticancer drugs that, depending on the surface modification, can exhibit different adsorption mechanisms and release.

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“…To this end, DOX‐loaded nanocarriers (1 ml, 1.2 mg/ml) were transferred into the dialysis tubes (MWCO = 6000 Da) and soaked in 40 ml phosphate‐buffered saline (PBS) under stirring for 48 h. To measure the concentration of dialysate, 2 ml of the media was taken as a sample at predetermined time intervals, and replaced with 2 ml of buffer solution. Dialysate drug concentration of the samples was quantified by measuring the absorption peak at 480 nm against corresponding standard calibration curves 37 …”

Section: Experimental Methodsmentioning

confidence: 99%

Fabrication of acid‐labile poly(2‐hydroxyethyl methacrylate) nanoparticles using aldazine‐based crosslinker as pH‐sensitive drug nanocarriers

Arjmand

Salami‐Kalajahi

Roghani‐Mamaqani

2021

Polymers for Advanced Techs

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Herein, 1,2‐bis[(E)‐4‐(allyloxy)benzylidene]hydrazine is prepared via allyloxylation reaction of 4,4′{[(1E,1′E)‐Hydrazine‐1,2‐diylidene]bis(methanylylidene)}diphenol, which is obtained from the reaction of 4‐hydroxybenzaldehyde and hydrazine hydrate. The final product is used as a pH‐labile crosslinker in the synthesis of drug carriers based on poly(2‐hydroxyethyl methacrylate) (PHEMA) via distillation precipitation polymerization (DPP). These drug carriers are pH‐responsive by complete cleavage of carriers that allow for active delivery of anticancer drug in cancerous tissues. The synthesized new compounds are characterized using attenuated total reflectance‐Fourier transform infrared spectroscopy (ATR‐FTIR), Raman spectroscopy, proton nuclear magnetic resonance (1H NMR), UV–Vis–NIR spectrophotometer, and fluorescence microscopy. To investigate the shape and size of the resultant nanoparticles, field emission scanning electron microscopy (FE‐SEM) and dynamic light scattering (DLS) are used. The in vitro drug release behavior of DOX‐loaded carriers is observed in various pH values and the results indicate that pH‐labile nanoparticles show excellent cumulative drug release during 48 h at pH = 1 as found to be 97.5 ± 1.4% and 98.8 ± 1.5% for drug carriers with 10 and 15 mol. % pH‐labile crosslinker, respectively.

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Investigating Janus morphology development of poly(acrylic acid)/poly(2‑(dimethylamino)ethyl methacrylate) composite particles: An experimental study and mathematical modeling of DOX release

Cited by 34 publications

References 48 publications

Synthesis of core‐shell and Janus polystyrene@polypyrrole particles by variation of surfactant and monomer amount through seeded emulsion polymerization

Synthesis of core‐shell and Janus polystyrene@polypyrrole particles by variation of surfactant and monomer amount through seeded emulsion polymerization

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

Fabrication of acid‐labile poly(2‐hydroxyethyl methacrylate) nanoparticles using aldazine‐based crosslinker as pH‐sensitive drug nanocarriers

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