2020
DOI: 10.1093/rb/rbaa018
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Investigating materials and orientation parameters for the creation of a 3D musculoskeletal interface co-culture model

Abstract: Musculoskeletal tissue interfaces are a common site of injury in the young, active populations. In particular, the interface between the musculoskeletal tissues of tendon and bone is often injured and to date, no single treatment has been able to restore the form and function of damaged tissue at the bone–tendon interface. Tissue engineering and regeneration hold great promise for the manufacture of bespoke in vitro models or implants to be used to advance repair and so this study investigated the material, or… Show more

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Cited by 7 publications
(10 citation statements)
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“…Although 2D models can give insight into the cellular interactions, there is a need for 3D models that more accurately recreate the native extracellular matrix and physiological microenvironment. Collagen models that are commonly used are highly hydrated and are mechanically weak [12]. Previous investigations on collagen hydrogels seeded with high-density bovine tenocytes and ligament fibroblasts induced cell-driven matrix remodelling that reached comparable mechanical properties of immature native tendon and ligament after 4-6 weeks of culture [37].…”
Section: Discussionmentioning
confidence: 99%
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“…Although 2D models can give insight into the cellular interactions, there is a need for 3D models that more accurately recreate the native extracellular matrix and physiological microenvironment. Collagen models that are commonly used are highly hydrated and are mechanically weak [12]. Previous investigations on collagen hydrogels seeded with high-density bovine tenocytes and ligament fibroblasts induced cell-driven matrix remodelling that reached comparable mechanical properties of immature native tendon and ligament after 4-6 weeks of culture [37].…”
Section: Discussionmentioning
confidence: 99%
“…For musculoskeletal tissues, in vivo models are preferred and remain the gold standard in preclinical studies due to a lack of reliable and biomimetic in vitro models [9]. In vivo models have been crucial in providing insight into enthesis development pathways [10,11], but a limited number of in vitro models have been developed [12][13][14]. Driven by the high occurrence of reconstruction surgeries for ligament and tendon tissues, there has been increased interest in providing bi-and tri-phasic scaffolds as alternative grafts, including differentiating mesenchymal stem cells into two lineages within the same scaffold [13,[15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%
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