Investigating metabolic dysregulation in serum of triple transgenic Alzheimer’s disease male mice: implications for pathogenesis and potential biomarkers
Hongbin Zhuang,
Xueshan Cao,
Xiaoxiao Tang
et al.
Abstract:Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease that lacks convenient and accessible peripheral blood diagnostic markers and effective drugs. Metabolic dysfunction is one of AD risk factors, which leaded to alterations of various metabolites in the body. Pathological changes of the brain can be reflected in blood metabolites that are expected to explain the disease mechanisms or be candidate biomarkers. The aim of this study was to investigate the changes of targeted metabolites within p… Show more
Trimethylamine N-Oxide (TMAO) metabolism has been recognized as a biomarker for early thrombosis detection. However, testing for TMAO typically requires expensive laboratory equipment and skilled technicians, making it unsuitable as...
Trimethylamine N-Oxide (TMAO) metabolism has been recognized as a biomarker for early thrombosis detection. However, testing for TMAO typically requires expensive laboratory equipment and skilled technicians, making it unsuitable as...
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