2020
DOI: 10.1088/1361-6560/ab63b5
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Investigating neutron activated contrast agent imaging for tumor localization in proton therapy: a feasibility study for proton neutron gamma-x detection (PNGXD)

Abstract: Proton neutron gamma-x detection (PNGXD) is a novel imaging concept being investigated for tumor localization during proton therapy that uses secondary neutron interactions with a gadolinium contrast agent (GDCA) to produce characteristic photons within the 40–200 keV energy region. The purpose of this study is to experimentally investigate the feasibility of implementing this procedure by performing experimental measurements on a passive double scattering proton treatment unit. Five experimental measurements … Show more

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Cited by 5 publications
(23 citation statements)
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“…This dynamic tumor image displayed in coincidence to treatment can be fused with a CT or MRI image series and used as a method to localize tumor position. The visible tumor image can be used as a method to indicate the effectiveness of treatment with each subsequent fractionation and provide spatial information for adaptive therapy techniques 9 . Also, dose enhancement was not investigated within this study, however, it is worth further investigation to determine if Gd dose enhancement would provide an impactful benefit to therapeutic treatment from any of these 10 particles.…”
Section: Discussionmentioning
confidence: 99%
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“…This dynamic tumor image displayed in coincidence to treatment can be fused with a CT or MRI image series and used as a method to localize tumor position. The visible tumor image can be used as a method to indicate the effectiveness of treatment with each subsequent fractionation and provide spatial information for adaptive therapy techniques 9 . Also, dose enhancement was not investigated within this study, however, it is worth further investigation to determine if Gd dose enhancement would provide an impactful benefit to therapeutic treatment from any of these 10 particles.…”
Section: Discussionmentioning
confidence: 99%
“…The application of novel dynamic-SPECT (D-SPECT) systems may allow a smaller treatment room presence with little reduction in imaging quality, however, further experimental investigation is needed. Experimental measurements performed on a 5 × 5 mm 2 cadmium telluride (CdTe) detector have documented signal-to-noise ratios as high as 15 9 . As proton range verification techniques such as positron emission tomography (PET) or prompt γ-ray emission also require the incorporation of a detection system, it may be possible to perform a PNGXD imaging procedure in-synchrony to a range verification technique 10 , 11 .…”
Section: Introductionmentioning
confidence: 99%
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