Investigating of physical, mechanical, and biological properties of polyhydroxybutyrate-keratin/alumina electrospun scaffold utilized in bone tissue engineering

Ghafari, Fereshte; Karbasi, Saeed; Eslaminejad, Mohamadreza Baghaban

doi:10.1016/j.matchemphys.2023.127340

Cited by 12 publications

(3 citation statements)

References 155 publications

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“…The desirable properties of the scaffold material for bone tissue engineering include good biocompatibility, biodegradability, and mechanical durability [48]. According to the results of the present study, BC has these necessary properties, and the ability to support mineral deposition as well as cell adhesion and proliferation, which all indicate that BC is an ideal scaffold material for bone tissue engineering.…”

Section: In Vivo Biocompatibility and Degradation Of The Bc Filmsupporting

confidence: 53%

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A Novel Porous Butyryl Chitin–Animal Derived Hydroxyapatite Composite Scaffold for Cranial Bone Defect Repair

Zhang

Jiang

Chi

et al. 2023

IJMS

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Bone defects, a common orthopedic problem in clinical practice, are a serious threat to human health. As alternative materials to autologous bone grafts, synthetic cell-free functionalized scaffolds have been the focus of recent research in designing scaffolds for bone tissue engineering. Butyryl chitin (BC) is a derivative of chitin (CT) with improved solubility. It has good biocompatibility, but few studies have investigated its use in bone repair. In this study, BC was successfully synthesized with a degree of substitution of 2.1. BC films were prepared using the cast film method and showed strong tensile strength (47.8 ± 4.54 N) and hydrophobicity (86.4 ± 2.46°), which was favorable for mineral deposition. An in vitro cytological assay confirmed the excellent cell attachment and cytocompatibility of the BC film; meanwhile, in vivo degradation indicated the good biocompatibility of BC. Hydroxyapatite (HA), extracted from bovine cancellous bone, had good cytocompatibility and osteogenic induction activity for the mouse osteoblast cell line MC3T3-E1. With the aim of combining the advantages of BC and HA, a BC–HA composite scaffold, with a good pore structure and mechanical strength, was prepared by physical mixing. Administered into skull defects of rats, the scaffolds showed perfect bone-binding performance and effective structural support, and significantly promoted the regeneration of new bone. These results prove that the BC–HA porous scaffold is a successful bone tissue engineering scaffold and has strong potential to be further developed as a substitute for bone transplantation.

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Section: In Vivo Biocompatibility and Degradation Of The Bc Filmsupporting

confidence: 53%

“…The ideal scaffold material for bone regeneration should have good mechanical strength [48], but solvents can impact the mechanical strength of the material [49]. According to the above results, ethanol is an ideal solvent, but the mechanical strength of the BC film, using ethanol as a solvent, needed to be determined.…”

Section: Characterization Of Bcmentioning

confidence: 99%

A Novel Porous Butyryl Chitin–Animal Derived Hydroxyapatite Composite Scaffold for Cranial Bone Defect Repair

Zhang

Jiang

Chi

et al. 2023

IJMS

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“…Natural polymers suitable for the preparation of nanofibers mainly fall into two categories: polysaccharides and proteins. Polysaccharides include chitosan [ 60 ], starch [ 61 ], alginates [ 62 ], hyaluronic acid [ 63 ], and cellulose [ 64 ]; while protein-based polymers include collagen [ 65 ], gelatin [ 66 ], fibrinogen [ 67 ], silk proteins [ 68 ], sericin [ 69 ], elastin [ 70 ], keratin [ 71 ], and plant proteins [ 72 ]. Table 1 lists the polymers that can be used to prepare nanofibrous scaffolds.…”

Section: Nanofiber Scaffold Technologymentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Jiang

Zheng

et al. 2023

Pharmaceutics

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Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, as well as their spatial structure which mimics the extracellular matrix. However, the use of nanofibers to achieve controlled drug loading and release still presents many challenges, with ongoing research still exploring how to load drugs onto nanofiber scaffolds without loss of activity and how to control their release in a specific spatiotemporal manner. This comprehensive study systematically reviews the applications and recent advances related to drug-laden nanofiber scaffolds for skin-wound management. First, we introduce commonly used methods for nanofiber preparation, including electrostatic spinning, sol–gel, molecular self-assembly, thermally induced phase separation, and 3D-printing techniques. Next, we summarize the polymers used in the preparation of nanofibers and drug delivery methods utilizing nanofiber scaffolds. We then review the application of drug-loaded nanofiber scaffolds for wound healing, considering the different stages of wound healing in which the drug acts. Finally, we briefly describe stimulus-responsive drug delivery schemes for nanofiber scaffolds, as well as other exciting drug delivery systems.

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Physico-mechanical Evaluation of Electrospun Nanofibrous Mats of Poly(3-hydroxybutyrate)/Poly(butylene succinate) Blends with Enhanced Swelling-Dynamics and Hydrolytic Degradation-Kinetics Stability for Pliable Scaffold Substrates

Peshne,

Das,

Sharma

et al. 2024

J Polym Environ

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Investigating of physical, mechanical, and biological properties of polyhydroxybutyrate-keratin/alumina electrospun scaffold utilized in bone tissue engineering

Cited by 12 publications

References 155 publications

A Novel Porous Butyryl Chitin–Animal Derived Hydroxyapatite Composite Scaffold for Cranial Bone Defect Repair

A Novel Porous Butyryl Chitin–Animal Derived Hydroxyapatite Composite Scaffold for Cranial Bone Defect Repair

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Physico-mechanical Evaluation of Electrospun Nanofibrous Mats of Poly(3-hydroxybutyrate)/Poly(butylene succinate) Blends with Enhanced Swelling-Dynamics and Hydrolytic Degradation-Kinetics Stability for Pliable Scaffold Substrates

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