Investigating paraoxonase-1 gene Q192R and L55M polymorphism in patients with renal cell cancer

Oa, Uyar; Kara, Murat; Erol, Deniz; Ardıcoglu, A.; Yüce, Hüseyin

doi:10.4238/vol10-1gmr927

Cited by 15 publications

(14 citation statements)

References 22 publications

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“…Lurie and colleagues [119] and Arpaci and colleagues [120] reported conflicting data regarding the impact of the rs662 SNP on the development of ovarian cancer. The G allele of this SNP was significantly more frequent in controls than in cases with renal cell carcinoma [121], which is consistent with the majority of the previously mentioned findings. However, Ozturk and associates [92] demonstrated that carrying this protective allele was associated with an increased risk of bladder cancer, which may be explained by a possible role of PON1 in the carcinogenesis of bladder epithelium and other acidic environments.…”

Section: Other Malignanciessupporting

confidence: 93%

“…No statistically significant associations were found between the rs854560 SNP and subjects with renal cell carcinoma [121], bladder cancer [92], colorectal carcinoma [125], and lung cancer [122]. De Roos and colleagues [126] established that the mutant AA genotype was a risk factor for the development of non-Hodgkin lymphoma, especially for follicular and T-cell subtypes in non-Hispanic, white subjects.…”

Section: Other Malignanciesmentioning

confidence: 99%

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Common Genetic Variants in the Myeloperoxidase and Paraoxonase Genes and the Related Cancer Risk: A Review

Yuzhalin

Kutikhin

2012

Journal of Environmental Science and Health, Part C

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Modern approaches in health care are moving toward the model of "personalized medicine." Today, current research in molecular biology and medicine is focused on developing genomic markers with predictive, therapeutic, and prognostic significance. One of the most widespread and significant genomic markers is the single nucleotide polymorphism (SNP), which represents a variation in DNA sequence when a single nucleotide differs between members of a biological species or paired chromosomes in an individual. Antioxidant defense enzymes break down dangerous reactive compounds, called reactive oxygen species, and prevent DNA strand from carcinogen-specific mutations. It is well known that inherited variations in genes that encode antioxidant defense enzymes may modulate individual susceptibility to cancer. In our previous study we have determined the predictive significance of several SNPs of superoxide dismutase (SOD) and glutathione peroxidase gene families in the context of cancer risk. The present review includes a summary and discussion of the current findings evaluating the role of SNPs of the myeloperoxidase (MPO) and paraoxanase (PON) genes in cancer occurrence and development. We suggest that rs2333227 (MPO_ -463G/A) and rs854560 polymorphisms have a great predictive significance; they could probably be utilized as cancer predictors in the future. Also, we recommend further in-depth research for rs11079344 (MPO), rs8178406 (MPO), rs2243828 (MPO), rs662 (PON1), rs705379 (PON1), and PON1_304A/G polymorphisms. These SNPs may become significant cancer-associated biomarkers.

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Section: Other Malignanciessupporting

confidence: 93%

Section: Other Malignanciesmentioning

confidence: 99%

Common Genetic Variants in the Myeloperoxidase and Paraoxonase Genes and the Related Cancer Risk: A Review

Yuzhalin

Kutikhin

2012

Journal of Environmental Science and Health, Part C

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“…Also, serum PON1 and arylesterase activities were reduced in patients with epithelial ovarian cancer [2] and lung cancer [3]. Uyar et al found that Q allele of PON1 was more frequent in renal cancer patients [4], and Antognelli at al. reported that certain PON1 genotypes were prone to increased risk of prostate cancer [5].…”

Section: Altered Expression Levels Of Paraoxonase Enzymes In Cancermentioning

confidence: 99%

Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer

Witte

Foerstermann²,

Devarajan³

et al. 2012

Journal of Lipids

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Cancer and atherosclerosis are major causes of death in western societies. Deregulated cell death is common to both diseases, with significant contribution of inflammatory processes and oxidative stress. These two form a vicious cycle and regulate cell death pathways in either direction. This raises interest in antioxidative systems. The human enzymes paraoxonase-2 (PON2) and PON3 are intracellular enzymes with established antioxidative effects and protective functions against atherosclerosis. Underlying molecular mechanisms, however, remained elusive until recently. Novel findings revealed that both enzymes locate to mitochondrial membranes where they interact with coenzyme Q10 and diminish oxidative stress. As a result, ROS-triggered mitochondrial apoptosis and cell death are reduced. From a cardiovascular standpoint, this is beneficial given that enhanced loss of vascular cells and macrophage death forms the basis for atherosclerotic plaque development. However, the same function has now been shown to raise chemotherapeutic resistance in several cancer cells. Intriguingly, PON2 as well as PON3 are frequently found upregulated in tumor samples. Here we review studies reporting PON2/PON3 deregulations in cancer, summarize most recent findings on their anti-oxidative and antiapoptotic mechanisms, and discuss how this could be used in putative future therapies to target atherosclerosis and cancer.

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“…It was shown that the GPX1 Leu allele was less responsive than the Pro allele during stimulation of the GPX1 enzyme activity by selenium supplementation in vitro (Uyar et al, 2011;Wei et al, 2011). The presence of a more frequent Pro allelle may make FMF patients more vulnerable to oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…It has been associated with the detoxification of organophosphates and possibly in the prevention of low-density lipoprotein oxidation (Biasioli et al, 2003). Two major genetic polymorphisms of PON1 have been described due to glutamine or arginine at position 192 (Q/R192) and methionine or leucine at position 55 (L/M) (Uyar et al, 2011). These polymorphisms are associated with difference in serum activities and concentrations of the enzymes (Adkins et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of paraoxonase1 192 and glutathione peroxidase1 197 enzymes in familial Mediterranean fever

Öktem¹,

Anıl²,

Sütçü³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Familial Mediterranean fever (FMF) is an autosomal recessive disorder and is the most frequent of the periodic febrile inflammatory syndromes. The pathogenesis of the disease is not completely understood, even though the FMF gene has been identified. Oxidative stress and inflammation may play a role in the pathogenesis of FMF. We investigated gene polymorphisms of the antioxidative enzymes, glutathione peroxidase (GPX) and paraoxonase (PON) in FMF patients, and possible associations with FMF pathogenesis. Sixty FMF patients during an attack-free period and 51 healthy children as the control group were included in our study. PON1 Q/R192 and GPX1 Pro197Leu gene polymorphisms were assayed. Blood urea nitrogen, creatinine and serum lipid profile were also measured. PON1 Q/R192 genotype distribution was 52% QQ, 46% QR and 2% RR in the FMF group and 45% QQ, 45% QR and 10% RR in the control group (P > Familial Mediterranean fever 0.05). GPX1 Pro197Leu genotype distribution was 28% PP, 57% PL, 15% LL in the FMF group and 18% PP, 53% PL, 29% LL in the control group (P > 0.05). Blood urea nitrogen, serum creatinine, lipid levels, and the distribution of PON1 Q/R192 and GPX1 Pro197Leu genotypes were similar in the two groups. We conclude that the PON1 Q/R192 and GPX1 Pro197Leu gene polymorphisms are not important risk factors in the development of FMF. However, larger studies are warranted to validate these conclusions.

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Investigating paraoxonase-1 gene Q192R and L55M polymorphism in patients with renal cell cancer

Cited by 15 publications

References 22 publications

Common Genetic Variants in the Myeloperoxidase and Paraoxonase Genes and the Related Cancer Risk: A Review

Common Genetic Variants in the Myeloperoxidase and Paraoxonase Genes and the Related Cancer Risk: A Review

Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer

Genetic polymorphisms of paraoxonase1 192 and glutathione peroxidase1 197 enzymes in familial Mediterranean fever

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