Investigating raised creatine kinase

Kim, Young Ho; Wierzbicki, Anthony S.

doi:10.1136/bmj.n1486

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…Third, blood creatine kinase (CK) levels were not analyzed in the present study. Although CK could be a marker reflecting statin‐induced muscle damage and muscle function, CK was not a routinely measured parameter in the study participants 42,43 . Future high‐quality prospective studies need to include CK in their analyses to examine the impact of statins on muscle health.…”

Section: Discussionmentioning

confidence: 99%

Statin use impairs muscle strength recovery in post‐stroke patients with sarcopenia

Matsumoto¹,

Yoshimura²,

Nagano³

et al. 2023

Geriatrics Gerontology Int

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AimThe effects of statins on muscle health are not well established. Therefore, this study investigated the impact of statin use on muscle strength and mass recovery in patients with sarcopenia after stroke.MethodsThis retrospective cohort study included stroke patients with sarcopenia hospitalized between 2015 and 2021 at a post‐acute rehabilitation hospital. Sarcopenia was diagnosed using handgrip strength and skeletal muscle mass index measured using bioelectrical impedance analysis according to the 2019 criteria of the Asian Working Group for Sarcopenia. The study outcomes included handgrip strength and skeletal muscle mass index at hospital discharge. We used multivariate analyses to examine whether statin use was independently associated with the outcomes. Statistical significance was set at P < 0.05.ResultsOf the 586 patients enrolled, 241 (mean age 79.3 years, 44.4% men) presented with sarcopenia and were included in the analysis. Statin use was observed in 61 (25.3%) patients. Statin use was independently negatively associated with handgrip strength at discharge (β = −0.095, P = 0.032), but not with skeletal muscle mass index at discharge (β = 0.019, P = 0.692).ConclusionsStatin use was negatively associated with muscle strength recovery, but not with muscle mass in patients with sarcopenia who underwent rehabilitation after stroke. To maximize outcomes, sufficient consideration is needed for statin use in these patients. Geriatr Gerontol Int 2023; ••: ••–••.

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Section: Discussionmentioning

confidence: 99%

Statin use impairs muscle strength recovery in post‐stroke patients with sarcopenia

Matsumoto¹,

Yoshimura²,

Nagano³

et al. 2023

Geriatrics Gerontology Int

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“…In other words, elevated serum creatine kinase is associated with obesity, increased WC and BMI, WC, WHR and increased insulin resistance, and increased risk of heart disease [71][72][73]. However, serum creatine kinase levels depend on various factors such as age, sex, muscle mass, and physical activity [74][75][76]. In the present study, the group with the highest tertile of dietary choline and betaine had higher serum creatine kinase levels, although this association was not significant.…”

Section: Discussionmentioning

confidence: 99%

The interactive relationship of dietary choline and betaine with physical activity on circulating creatine kinase (CK), metabolic and glycemic markers, and anthropometric characteristics in physically active young individuals

Soleimani¹,

Ardekani²,

Fayyazishishavan³

et al. 2023

BMC Endocr Disord

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Background There is conflicting evidence on the relationship between dietary choline and betaine with metabolic markers and anthropometric characteristics. The aim of this study is to investigate the relationship between the interaction effects of dietary choline and betaine and physical activity (PA) on circulating creatine kinase (CK), metabolic and glycemic markers, and anthropometric characteristics in active youth. Methods In this cross-sectional study, data were collected from 120 to 18 to 35-year-old people. The food frequency questionnaire was used to assess dietary data; United States Department of Agriculture website was used to calculate choline and betaine in foods. CK, fasting blood sugar (FBS) and lipid profile markers were measured with ELISA kits. Low-density lipoprotein, and insulin sensitivity markers were calculated. Sociodemographic status, physical activity, and anthropometric characteristics were assessed based on a valid and reliable method. Analysis of co-variance (ANCOVA) tests adjusted for sex, PA, age, energy, and body mass index were used. Results Increasing dietary betaine and total choline and betaine was positively related to weight, waist-to-hip ratio, fat-free mass and bone mass (P < 0.05). Increasing dietary betaine lowered total cholesterol (P = 0.032) and increased high density lipoprotein (HDL) (P = 0.049). The interaction effect of dietary choline and physical activity improved insulin resistance (P < 0.05). As well as dietary betaine interacted with physical activity increased HDL (P = 0.049). In addition, dietary total choline and betaine interacted with physical activity decreased FBS (P = 0.047). Conclusions In general, increasing dietary choline and betaine along with moderate and high physical activity improved insulin resistance, increased HDL, and lowered FBS in the higher tertiles of dietary choline and betaine.

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