Investigating retinal explant models cultured in static and perfused systems to test the performance of exosomes secreted from retinal organoids

Yang, Tingting; Wang, Wenxuan; Xie, Linyao; Chen, Sihui; Ye, Xiuhong; Shen, Shuhao; Chen, Hang; Qi, Ling; Cui, Zekai; Xiong, Wei; Guo, Yonglong; Chen, Jiansu

doi:10.1016/j.jneumeth.2024.110181

Journal of Neuroscience Methods

2024

DOI: 10.1016/j.jneumeth.2024.110181

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Investigating retinal explant models cultured in static and perfused systems to test the performance of exosomes secreted from retinal organoids

Tingting Yang,

Wenxuan Wang,

Linyao Xie

et al.

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Cited by 1 publication

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Nanomedicine in Ophthalmology: From Bench to Bedside

Mahaling,

Baruah,

Dinabandhu

2024

JCM

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Ocular diseases such as cataract, refractive error, age-related macular degeneration, glaucoma, and diabetic retinopathy significantly impact vision and quality of life worldwide. Despite advances in conventional treatments, challenges like limited bioavailability, poor patient compliance, and invasive administration methods hinder their effectiveness. Nanomedicine offers a promising solution by enhancing drug delivery to targeted ocular tissues, enabling sustained release, and improving therapeutic outcomes. This review explores the journey of nanomedicine from bench to bedside, focusing on key nanotechnology platforms, preclinical models, and case studies of successful clinical translation. It addresses critical challenges, including pharmacokinetics, regulatory hurdles, and manufacturing scalability, which must be overcome for successful market entry. Additionally, this review highlights safety considerations, current marketed and FDA-approved nanomedicine products, and emerging trends such as gene therapy and personalized approaches. By providing a comprehensive overview of the current landscape and future directions, this article aims to guide researchers, clinicians, and industry stakeholders in advancing the clinical application of nanomedicine in ophthalmology.

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Nanomedicine in Ophthalmology: From Bench to Bedside

Mahaling,

Baruah,

Dinabandhu

2024

JCM

View full text Add to dashboard Cite

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scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Investigating retinal explant models cultured in static and perfused systems to test the performance of exosomes secreted from retinal organoids

Cited by 1 publication

References 82 publications

Nanomedicine in Ophthalmology: From Bench to Bedside

Nanomedicine in Ophthalmology: From Bench to Bedside

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