Investigating sphingolipids as biomarkers for the outcomes of acute ischemic stroke patients receiving endovascular treatment

Lee, Tsung-Heng; Cheng, C. H.; Lee, Chung-Wei; Kuo, Ching‐Hua; Tang, Sung‐Chun; Jeng, Jiann‐Shing

doi:10.1016/j.jfma.2022.08.021

Cited by 7 publications

(1 citation statement)

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“…Variations in sphingolipid metabolites plasma levels have also been associated with numerus metabolic and vascular diseases [53]. Long-chain ceramides are involved in apoptotic pathways and inflammation related to cerebral ischemia [54] and their elevated serum levels have been reported as predictors of risk and severity of the ischemic stroke [55,56] as well as related to adverse cardiovascular risk and events [57]. Rise in ceramide levels is a result of inflammation and tissue damage as well as a product of a strong increase in acidic and/or neutral sphingomyelinase activity (ASM/NSM), producing ceramide from sphingomyelin, which was reported to occur in focal cerebral ischemia [58].…”

Section: Discussionmentioning

confidence: 99%

Comparative Targeted Metabolomics in Ischemic Stroke Patients: Profiling Thrombi and Serums Samples for Identification of Stroke-related Metabolites

Karmelić,

Rubić,

Starčević

et al. 2024

Preprint

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Ischemic stroke is one of the leading causes of death and permanent disability in the world. Rapid diagnosis and intervention are crucial for reducing its consequences on individuals and societies. Identifying reliable biomarkers for early detection, prognostics and therapy is a criti-cal imperative for improving the stroke patient treatment. Metabolomics has been shown as a promising tool for biomarker discovery since many of the post-ischemic metabolites can found in the plasma or serum of the patient. In this research, we have performed comparative targeted metabolomic analysis of stroke thrombi, patient serums and healthy control serums in order to determine the alteration in the patients’ metabolome. The most statistically altered metabolites characterized in patient compared to control serums were glutamate and serotonin, followed by several lipid metabolites (phospholipids and triacylglycerols) and glucose. In stroke thrombi compared to patient’s serums, the most significantly altered metabolites were classified as li-pids, with choline-containing phospholipids and sphingomyelins having the highest discrimi-natory score. The results of this study could help in understanding the roles of different meta-bolic changes occurring during thrombosis and cerebral ischemia and possibly suggest new metabolic biomarkers of the ischemic stroke.

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Section: Discussionmentioning

confidence: 99%

Comparative Targeted Metabolomics in Ischemic Stroke Patients: Profiling Thrombi and Serums Samples for Identification of Stroke-related Metabolites

Karmelić,

Rubić,

Starčević

et al. 2024

Preprint

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Kao¹

2023

Journal of the Formosan Medical Association

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Body fluids biomarkers associated with prognosis of acute ischemic stroke: progress and prospects

Jiang,

Li,

et al. 2024

Future Science OA

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Acute ischemic stroke (AIS) is one of the most common strokes posing a grave threat to human life and health. Predicting the prognosis of AIS allows for an understanding of disease progress, and a better quality of life by making individualized treatment scheme. In this paper, we conducted a systematic search on PubMed, focusing on the relevant literature in the last 5 years. Summarizing the candidate prognostic biomarkers of AIS in body fluids such as blood, urine, saliva and cerebrospinal fluid is often of great significance for the management of acute ischemic stroke, which has the potential to facilitate early diagnosis, treatment, prevention and long-term outcome improvement.

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Investigating sphingolipids as biomarkers for the outcomes of acute ischemic stroke patients receiving endovascular treatment

Cited by 7 publications

References 35 publications

Comparative Targeted Metabolomics in Ischemic Stroke Patients: Profiling Thrombi and Serums Samples for Identification of Stroke-related Metabolites

Comparative Targeted Metabolomics in Ischemic Stroke Patients: Profiling Thrombi and Serums Samples for Identification of Stroke-related Metabolites

Highlights

Body fluids biomarkers associated with prognosis of acute ischemic stroke: progress and prospects

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