This article notes the geographical location and soil-climatic conditions of Kashkadarya province in Uzbekistan, as well as the mechanical composition, agrochemical properties and dynamics of nutrients in the soil of field experiments conducted in the conditions of typical irrigated gray soils in Shakhrisabz district. In total, 36% of the irrigated soils of the Kashkadarya basin are typical gray soils, and the genetic layers of the soils of the studied area are medium sandy, with large dust particles predominating in the mechanical fraction and create nutritional regimens. In the driving layers of the studied soils, humus 1.094%, total nitrogen 0.080%, total phosphorus 0.168%, total potassium 1.07%, mobile nitrogen, phosphorus and exchangeable potassium belong to low and moderately supplied groups. It is also possible to fully demonstrate the potential of cotton by creating a scientifically based nutrient environment for the promising variety “Porlok-4”.