Investigating the Alleviating Effects of &lt;em&gt;Bacillus cereus&lt;/em&gt; Administration on Colitis through Gut Microbiota Modulation

Sheng, Kangliang; Xu, Yifan; Yang, Jian; Ren, Huajian; Su, Ziwei; Wang, Yongzhong

doi:10.3791/63707

Cited by 1 publication

(1 citation statement)

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“…While the administration of spores and vegetative cells of B. cereus F4433/73R to rats did not cause substantial alterations in the gut community by PCR-DGGE, concomitant plate counts described a significant reduction in the total amount of coliforms, aerobes, and anaerobes [ 53 ]. In mice, the ingestion of the probiotic B. cereus strain HMPM18123 was demonstrated to ameliorate symptoms of dextran sulfate sodium (DSS)-induced colitis, by improving intestinal barrier integrity, reducing local inflammation and macrophage infiltration, and modulating the gut microbiota [ 54 , 179 ]. Microbial diversity was partially restored in B. cereus -treated mice, with higher abundances of Bacillota , Verrucomicrobiota , Lachnospiraceae , Muribaculaceae , Rikenellaceae , Akkermansia , Jeotgalicoccus , Lactobacillus , and Roseburia , and lower levels of Pseudomonadota , Prevotellaceae , and Bacteroides than in DSS-induced colitis models [ 54 ].…”

Section: Intestinal Pathogens and Gut Microbiotamentioning

confidence: 99%

Animal and In Vitro Models as Powerful Tools to Decipher the Effects of Enteric Pathogens on the Human Gut Microbiota

Calvigioni,

Mazzantini,

Celandroni

et al. 2023

Microorganisms

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Examining the interplay between intestinal pathogens and the gut microbiota is crucial to fully comprehend the pathogenic role of enteropathogens and their broader impact on human health. Valid alternatives to human studies have been introduced in laboratory practice to evaluate the effects of infectious agents on the gut microbiota, thereby exploring their translational implications in intestinal functionality and overall health. Different animal species are currently used as valuable models for intestinal infections. In addition, considering the recent advances in bioengineering, futuristic in vitro models resembling the intestinal environment are also available for this purpose. In this review, the impact of the main human enteropathogens (i.e., Clostridioides difficile, Campylobacter jejuni, diarrheagenic Escherichia coli, non-typhoidal Salmonella enterica, Shigella flexneri and Shigella sonnei, Vibrio cholerae, and Bacillus cereus) on intestinal microbial communities is summarized, with specific emphasis on results derived from investigations employing animal and in vitro models.

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