Investigating the Angiogenic Modulating Properties of Spirostachys africana in MCF-7 Breast Cancer Cell Line

Direko, Paballo; Mfengwana, Hildah; Mashele, Samson Sitheni; Sekhoacha, Mamello

doi:10.3923/ijp.2019.970.977

International J. of Pharmacology

2019

DOI: 10.3923/ijp.2019.970.977

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Investigating the Angiogenic Modulating Properties of Spirostachys africana in MCF-7 Breast Cancer Cell Line

Paballo Direko¹,

Hildah Mfengwana²,

Samson Sitheni Mashele³

et al.

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Cited by 2 publications

References 21 publications

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Effective Use of Euphorbia milii DCM Root Extract Encapsulated by Thermosensitive Immunoliposomes for Targeted Drug Delivery in Prostate Cancer Cells

Riet,

Adegoke,

Mashele

et al. 2024

CIMB

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The delivery of anticancer drugs using nanotechnology is a promising approach aimed at improving the therapeutic efficacy and reducing the toxicity of chemotherapeutic agents. Liposomes were prepared using HSPC: DSPE–PEG–2000: DSPE–PEG2000–maleimide in the ratio of 4:1:0.2 and conjugated with a PSA antibody. Euphorbia milii extract (EME), doxorubicin (Dox), and docetaxel (Doc) encapsulated in temperature–sensitive immunoliposomes were investigated for their activities against the prostate cancer LNCap and DU145 cell lines. Organic extracts of EME leaves, roots, and stems were screened against both cell lines, inhibiting more than 50% of cell culture at concentrations of 10 μg/mL. The immunoliposomes incorporating the EME and docetaxel were active against the LNCap cells when exposed to heat at 39–40 °C. The liposomes not exposed to heat were inactive against the LNCap cells. The developed heat-sensitive immunoliposomes used for the delivery of both the EME and chemotherapeutic agents was able to successfully release the entrapped contents upon heat exposure above the phase transition temperature of the liposome membrane. The heat-sensitive immunoliposomes conjugated with a PSA antibody encapsulated the extract successfully and showed better cell antiproliferation efficacy against the prostate cancer cell lines in the presence of heat.

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Effective Use of Euphorbia milii DCM Root Extract Encapsulated by Thermosensitive Immunoliposomes for Targeted Drug Delivery in Prostate Cancer Cells

Riet,

Adegoke,

Mashele

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

Cytotoxicity and Chromatographic Fingerprinting of Euphorbia Species Used in Traditional Medicine

Mampa¹,

Mashele²,

Sekhoacha³

2020

Pakistan J. of Biological Sciences

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Investigating the Angiogenic Modulating Properties of Spirostachys africana in MCF-7 Breast Cancer Cell Line

Cited by 2 publications

References 21 publications

Effective Use of Euphorbia milii DCM Root Extract Encapsulated by Thermosensitive Immunoliposomes for Targeted Drug Delivery in Prostate Cancer Cells

Effective Use of Euphorbia milii DCM Root Extract Encapsulated by Thermosensitive Immunoliposomes for Targeted Drug Delivery in Prostate Cancer Cells

Cytotoxicity and Chromatographic Fingerprinting of Euphorbia Species Used in Traditional Medicine

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