Investigating the antibacterial activity of salen/salophene metal complexes: Induction of ferroptosis as part of the mode of action

Baecker, Daniel; Sesli, Özcan; Knabl, Ludwig; Huber, Silke; Orth‐Höller, Dorothea; Gust, Ronald

doi:10.1016/j.ejmech.2020.112907

Cited by 42 publications

(29 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cellular uptake of the β-lactam antibiotics ATM (dissolved in water: dimethylformamide [DMF; 1:1]; Acros Organics, Geel, Belgium) and CAZ (dissolved in 0.1 M NaOH; Acros Organics, Geel, Belgium) and the non-β-lactam β-lactamase inhibitor AVI (dissolved in water; BioVision, Milpitas, CA, USA) was investigated by determining the increased cellular content of sulfur in terms of carbon monosulfide ( λ = 258.0330 nm) based on uptake of the sulfurous compounds by using high-resolution continuum-source molecular absorption spectrometry (HR CS MAS) based on the graphite furnace technique. This investigation refers to experiments described previously ( 136 ) with minor modifications. First, overnight cultures were set to an OD 600 of 0.3 turbidity (approximately 1.5 × 10 8 CFU/mL).…”

Section: Methodsmentioning

confidence: 99%

Extensively Drug-Resistant Klebsiella pneumoniae Counteracts Fitness and Virulence Costs That Accompanied Ceftazidime-Avibactam Resistance Acquisition

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Extensively Drug-Resistant Klebsiella pneumoniae Counteracts Fitness and Virulence Costs That Accompanied Ceftazidime-Avibactam Resistance Acquisition

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Gram-negative bacteria have an additional outer membrane structure with the outer-lipid leaflet containing lipopolysaccharides [53]. This makes Gram-negative bacteria more resistant to antimicrobial agents that are unable to cross this additional layer [54] as shown by several studies [55,56].…”

Section: Minimum Inhibitory Concentration Determinationmentioning

confidence: 99%

Synthesis and Evaluation of 3-Halobenzo[b]thiophenes as Potential Antibacterial and Antifungal Agents

et al. 2021

View full text Add to dashboard Cite

The global health concern of antimicrobial resistance has harnessed research interest to find new classes of antibiotics to combat disease-causing pathogens. In our studies, 3-halobenzo[b]thiophene derivatives were synthesized and tested for their antimicrobial activities using the broth microdilution susceptibility method. The 3-halo substituted benzo[b]thiophenes were synthesized starting from 2-alkynyl thioanisoles using a convenient electrophilic cyclization methodology that utilizes sodium halides as the source of electrophilic halogens when reacted along with copper(II) sulfate. This environmentally benign methodology is facile, uses ethanol as the solvent, and results in 3-halo substituted benzo[b]thiophene structures in very high yields. The cyclohexanol-substituted 3-chloro and 3-bromobenzo[b]thiophenes resulted in a low MIC of 16 µg/mL against Gram-positive bacteria and yeast. Additionally, in silico absorption, distribution, metabolism, and excretion (ADME) properties of the compounds were determined. The compounds with the lowest MIC values showed excellent drug-like properties with no violations to Lipinski, Veber, and Muegge filters. The time-kill curve was obtained for cyclohexanol-substituted 3-chlorobenzo[b]thiophenes against Staphylococcus aureus, which showed fast bactericidal activity at MIC.

show abstract

“…Salen and Salophen ligands are particularly appealing among these ligands. Metal-Salen and Salophen complexes have been intensively explored in medicinal [4][5][6] as well as material [7][8][9] chemistry in addition to their well-known catalytic characteristics in organic synthesis [10,11] and chemo sensing applications [12][13][14][15]. e ability of tetradentate Salophen ONNO ligands to coordinate a wide range of transition metals in various oxidation states explains their appeal.…”

Section: Introductionmentioning

confidence: 99%

Electronic Impacts on the Solvent-Free Mechanochemical Synthesis of Salophen Ligands in Ball Mill

Tigineh

2022

Journal of Chemistry

View full text Add to dashboard Cite

To realize the scope of the solid-solid reaction, the functional solid diamines reacted with solid 3-ethoxysalicylaldehyde under high-speed ball milling in a solvent-free environment. The findings showed that a wide range of Salophen ligands could be produced in good to excellent yields. In comparison to the similar Salophen synthesis to date, the current study provided solvent-free, fast reaction, high yield, and easy work-up.

show abstract

Investigating the antibacterial activity of salen/salophene metal complexes: Induction of ferroptosis as part of the mode of action

Cited by 42 publications

References 50 publications

Extensively Drug-Resistant Klebsiella pneumoniae Counteracts Fitness and Virulence Costs That Accompanied Ceftazidime-Avibactam Resistance Acquisition

Extensively Drug-Resistant Klebsiella pneumoniae Counteracts Fitness and Virulence Costs That Accompanied Ceftazidime-Avibactam Resistance Acquisition

Synthesis and Evaluation of 3-Halobenzo[b]thiophenes as Potential Antibacterial and Antifungal Agents

Electronic Impacts on the Solvent-Free Mechanochemical Synthesis of Salophen Ligands in Ball Mill

Contact Info

Product

Resources

About