Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer

Chen, S.; Liu, Y.L.; Wang, C.; Zhang, Kaiguang

doi:10.4238/gmr.15038342

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…XRCC1 plays a key role in mediating the repair of single-stranded DNA breaks as part of the BER pathway, with SNPs in this gene having the potential to alter or compromise protein functionality (3,19,24,25). Mutations in XRCC1 have been linked with many different cancer types, including hepatocellular carcinoma, thyroid carcinoma, nasopharyngeal carcinoma, and lung, bladder, gastric, and cervical cancers (16,(26)(27)(28)(29)(30)(31)(32). Previous studies have focused largely on three different XRCC1 polymorphisms when assessing their relationship with esophageal cancer risk, including Arg280His, Arg194Trp, and Arg399Gln (3,11,13,33).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of the correlation between base‑excision repair gene SNPs and esophageal squamous cell carcinoma risk in a Chinese Han population

et al. 2020

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This study sought to assess the relationship between single nucleotide polymorphisms (SNPs) affecting DNA base-excision repair (BER) genes and esophageal squamous cell carcinoma (ESCC) risk in a Han Chinese population. Genes screened for such SNPs included 8-oxoguanine DNA glycosylase (OGG1), apurinic/apyrimidinic endonuclease 1 (APE1) and X-ray repair cross-complementing group 1 protein (XRCC1). Blood samples that had been collected in a prospective manner were used for DNA extraction, with all DNA samples then being subjected to PCR-restriction fragment length polymorphism genotyping for BER gene SNPs, including APE1 Asp148Glu and-141T/G, OGG1 Ser326Cys, and XRCC1 Arg399Gln. The relationship between these SNPs and ESCC risk was then assessed, with the comparability of the case and control groups being enhanced via propensity score matching (PSM). This study initially included 642 healthy controls and 321 ESCC patients, with PSM optimization leading to a final analyzed total of 311 matched subjects per group (311 total). Factors associated with elevated ESCC risk in this analysis included advanced age, being male and smoking. We further identified that the XRCC1 399 Gln/Gln genotype was associated with a significant reduction in ESCC risk prior to propensity matching (odds ratio=0.48; 95% CI: 0.23-1.00; P<0.05), although this did not remain true following matching. For the remaining analyzed SNPs, no significant associations between genotype and ESCC risk were detected prior to or following propensity matching. A multivariate analysis incorporating patient age, sex, smoking status and drinking status failed to detect any relationship between the four tested genotypes and ESCC risk. In conclusion, being male, a smoker or of advanced age was associated with an elevated ESCC risk. However, we did not detect any significant relationship between ESCC risk and BER polymorphisms in XRCC1, OGG1, APE1 or the APE1 promoter region in a Han Chinese population.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of the correlation between base‑excision repair gene SNPs and esophageal squamous cell carcinoma risk in a Chinese Han population

et al. 2020

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“…A meta-analysis found the G allele is one of the risk factors in developing of Glioma in Asians [ 84 ]. Another meta-analysis carried out on a Chinese population found XRCC1 Arg399Gln polymorphism is not associated with BC (at the 5% level) but indicated a borderline association [ 85 ].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in BER genes and risk of breast cancer: evidences from 69 studies with 33760 cases and 33252 controls

et al. 2018

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Recently, numerous studies have reported an association between single nucleotide polymorphisms in base-excision repair genes and the risk of developing breast cancer, however there is no consensus. The aim of this meta-analysis was to review and quantitatively assess the relationship between single nucleotide polymorphisms in base-excision repair genes and breast cancer risk. The results suggested that a mutation of T to G in rs1760944 may lead to a higher risk of developing breast cancer in the Mongoloid population, and G to A of rs25487 significantly reduced the risk of breast cancer in Mongoloid and Caucasoid populations. In contrast to the CC and CG genotypes, the GG genotype of rs1052133 located on theOGG1 gene appeared to be a protective factor against developing breast cancer in both Mongoloid and Caucasoid populations. There was no evidence to suggest that rs25489, rs1799782, rs1130409, rs1805414 and rs1136410 were associated with breast cancer risk. In conclusion, this study provides evidence to support the theory that DNA repair genes are associated with breast cancer risk, providing information to further understand breast cancer etiology. and The potential biological pathways linking DNA repair, ethnic background, environment and breast cancer require further investigation.

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“…Several studies indicated an association between XRCC1 genetic polymorphisms and a variety of cancers such as gastric (Chen et al, 2016), lung (Cătană et al, 2015), thyroid (Wang et al, 2015) and breast cancer (Bu et al, 2014). This study aimed to investigate c.1517G>C SNP of XRCC1 gene as HCC risk factor in Egyptian population.…”

Section: Introductionmentioning

confidence: 99%

XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population

Naguib

Helwa

Soliman

et al. 2020

Asian Pac J Cancer Prev

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Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer

Cited by 7 publications

References 19 publications

Comprehensive analysis of the correlation between base‑excision repair gene SNPs and esophageal squamous cell carcinoma risk in a Chinese Han population

Comprehensive analysis of the correlation between base‑excision repair gene SNPs and esophageal squamous cell carcinoma risk in a Chinese Han population

Polymorphisms in BER genes and risk of breast cancer: evidences from 69 studies with 33760 cases and 33252 controls

XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population

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