Investigating the Bactericidal Mechanism of Three Novel Histone-Derived Antimicrobial Peptides

Abstract

Peptide-lipid interactions are pertinent to antimicrobial peptides (AMP) activity, stringency, and selectivity. The ability of AMPs to disrupt the target cell's lipid bilayer has been described using the nonspecific ''carpet'' model or using models that assume stable transbilayer pores (e.g. barrel stave pores). With the