Investigating the Biological Activity of Imidazolium Aurate Salts

Abstract

We report herein the biological activities of several imidazolium aurate(I) salts. The cytotoxicity on three cell‐lines (i. e. Hela, H460 and 3T3), enzyme inhibition on a panel of five enzymes (i. e. prolyl endopeptidase, butyrylcholinesterase, tyrosinase, dipeptidyl peptidase and carbonic anhydrase), iron chelation and in vitro Leishmanicidal assay for promastigotes are described. A comparison with other data found in the literature using similar standards to our control experiment is also discussed. Finally, all these data lead us to establish some structure‐activity correlations and to determine the potential importance of the gold moiety in these salts.

Mechanisms of action of ionic liquids on living cells: the state of the art

“… Inhibition of superoxide dismutase (SOD) and catalase (CAT) activities, reduction of glutathione (GSH) content, and increase of the activity of caspase-3 have been observed in QGY-7701 cells incubated in [C 8 mim][Cl] (Jing et al 2013 ). Selective inhibition of butrylcholinesterase enzyme has been observed in HeLa, H460 (lung), and NIH/3T3 cell lines after incubation in imidazolium aurate-based ILs (Sioriki et al 2019 ). The selectivity character of these ILs has been determined by investigating their inhibition ability against several enzymes, including prolyl-endopeptidase, butryl-cholinesterase, tyrosinase, dipeptidyl peptidase IV, and carbonic anhydrase.…”

“…Selective inhibition of butrylcholinesterase enzyme has been observed in HeLa, H460 (lung), and NIH/3T3 cell lines after incubation in imidazolium aurate-based ILs (Sioriki et al 2019 ). The selectivity character of these ILs has been determined by investigating their inhibition ability against several enzymes, including prolyl-endopeptidase, butryl-cholinesterase, tyrosinase, dipeptidyl peptidase IV, and carbonic anhydrase.…”

“…Usually, the effect of anions is moderate in the sense that it does not change the order of magnitude of the EC50; however, few exceptions have been observed. For example, it has been shown that aureate anions reduce the EC50 by three orders of magnitude (Sioriki et al 2019 ). In the same study, it has been pointed out that unsaturated-ring imidazolium-based ILs have lower EC50 than saturated cases.…”

The Potential Role of Ionic Liquid as a Multifunctional Dental Biomaterial

“…This underscores a clear relationship between IL structure and toxicity, offering prospects for developing less harmful ILs. Even appropriate anions can reduce the half-maximal effective concentration (EC50) values by three orders of magnitude [116]. It is worth noting that when ILs encounter water or other polar solvents, they may undergo ion exchange, forming new substances with potentially different toxic properties.…”