Investigating the choriocapillaris and choroidal vasculature with new optical coherence tomography technologies

Ferrara, Daniela; Waheed, Nadia K.; Duker, Jay S.

doi:10.1016/j.preteyeres.2015.10.002

Cited by 242 publications

(198 citation statements)

References 256 publications

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“…26,27 New OCT technologies have substantially improved our capability in qualitatively and quantitatively evaluating the choroidal vasculature and perfusion. 28,29 OCT-Angiography (OCT-A), a recent label-free imaging modality that uses the blood cells motion as contrast, is able to provide information on the blood flow in the chorioretinal microvasculature. 30,31 In the present study, we used OCT-A to examine the choroidal vascular response of patients with CSCR to an abrupt increase of BP induced by isometric exercise.…”

Section: Resultsmentioning

confidence: 99%

Choroidal Vascular Reactivity in Central Serous Chorioretinopathy

Piccolino

Lupidi

Cagini

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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METHODS. For this multicenter, observational, case-control study, we enrolled 35 patients with an established diagnose of CSCR and 25 age-matched healthy controls. All subjects underwent a handgrip isometric exercise to obtain elevation of blood pressure (BP). In the resting phase and during the physical effort, macular OCT-angiograms were acquired. Systemic hemodynamic data were recorded at baseline and during stress conditions using an electronic sphygmomanometer. The analysis of vascular density (VD) of the choriocapillaris (CC) was performed on OCT-angiograms. The results obtained in CSCR patients, both at baseline and during the stress test, were compared with those of healthy subjects. RESULTS.Baseline and under stress values of systolic BP, diastolic BP, and mean arterial pressure were significantly higher (P < 0.05) in CSCR patients compared to controls, reaching values in the range of hypertension during the exercise. Baseline VD values of the CC were significantly lower (P < 0.05) in CSCR cases compared to healthy subjects. We noticed a significant increase (P < 0.05) in these values under stress condition in CSCR patients and not in controls.CONCLUSIONS. The present study suggests that choroidal blood flow is dysregulated in CSCR. During physical stress, CSCR patients easily reach critical values of BP that are not dampened by compensatory mechanisms in the choroidal vessels, as it happens in healthy subjects. The CC in CSCR could be particularly vulnerable to variations of systemic hemodynamics.

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Section: Resultsmentioning

confidence: 99%

Choroidal Vascular Reactivity in Central Serous Chorioretinopathy

Piccolino

Lupidi

Cagini

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…En face SS-OCT images were retrospectively evaluated and compared with FA and ICGA findings by three of four investigators (WJL, JWL, BRL) in a blinded fashion. The presence and the patterns of choroidal vascular dilatation were evaluated using the method introduced in several previous studies 19 22 23. For standardised comparison, reference photographs were used (figure 1).…”

Section: Methodsmentioning

confidence: 99%

En face choroidal vascular feature imaging in acute and chronic central serous chorioretinopathy using swept source optical coherence tomography

Lee

Park

et al. 2016

Br J Ophthalmol

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“…The decorrelation signal can be more sensitive to slower flows if the time between consecutive crosssectional scans is increased. However, by doing so, OCTA also becomes more sensitive to eye motion, which increases artifact image noise [30]. An interesting approach is the variable interscan time analysis (VISTA) algorithm which was firstly described by Choi and colleagues [27,31], a tool that allows for distinguishing varying degrees of CC flow impairment.…”

Section: Heidelberg Spectralismentioning

confidence: 99%

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Lauermann¹,

Eter²,

Alten³

2018

Ophthalmologica

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The choriocapillaris (CC) represents a fundamentally important vascular layer that is subject to physiologic changes with increasing age and that is also associated with a wide range of chorioretinal diseases. So far, information on blood flow in this specific layer has remained limited. With the advent of optical coherence tomography angiography (OCTA), new perspectives and possibilities of CC imaging have begun to evolve. This article shall review the opportunities and challenges of applying OCTA technology to the CC layer and summarize the current clinical efforts in OCTA CC imaging exemplarily in dry age-related macular degeneration and central serous chorioretinopathy.

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Investigating the choriocapillaris and choroidal vasculature with new optical coherence tomography technologies

Cited by 242 publications

References 256 publications

Choroidal Vascular Reactivity in Central Serous Chorioretinopathy

Choroidal Vascular Reactivity in Central Serous Chorioretinopathy

En face choroidal vascular feature imaging in acute and chronic central serous chorioretinopathy using swept source optical coherence tomography

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

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