Investigating the Coordination/Binding Events of Biologically Relevant Monosaccharides with New Mononuclear Iron(III) and Zinc(II) Complexes in Aqueous Solution

Abstract

New water-soluble mononuclear iron(III) and zinc(II) complexes, (Me 4 N) 4 [Fe 2 OCl 6 ][Fe(pbal)Cl 3 ] 2 (1), (Me 4 N)[Fe(pbal)(NO 3 ) 3 ] (2) and (Me 4 N)[Zn(pbal)Cl 2 ] (3)(Hpbal = N-(2-pyridylmethyl)-b-alanine) have been synthesized and fully characterized. The interactions of the complexes with biologically relevant monosaccharides, such as D-glucose, D-xylose and D-mannose have been studied by UV-Vis, 13 C NMR and ESI-MS techniques in alkaline aqueous solution. All the monosaccharides bind to metal complexes in 1:1 molar ratio. Binding-induced gradual increase in the absorption intensities of 1 and 2 has been observed in the UV-Vis spectra, with a significant blue shift of absorption maxima of the complexes upon increasing the concentration of monosaccharides. The binding ability and binding mode of these monosaccharides with 3 are identified by their characteristic coordination-induced shift (CIS) values for carbon atoms C1 and C2 in the 13 C NMR spectra. The ESI-MS for the complexes under the same experimental conditions but in the presence of one mol equiv. of the applied monosaccharides indicate the formation of complex/monosaccharide-bound associations in solution.

Carboxylate Bridge Controlled Formation of Tetra‐ and Pentanuclear Nickel(II) Complexes: Synthesis, Crystal Structure, Spectroscopy and Magnetic Properties

“…More recently, we have utilized the ligand HL for the synthesis of new cyclic tetranuclear copper(II) complexes containing quadrilateral cores showing DNA binding affinity in aqueous solution . Employing this ligand, we have also reported the coordination‐cum‐binding events of biologically relevant monosaccharides such as D‐glucose, D‐xylose and D‐mannose with new mononuclear iron(III) and zinc(II) complexes in aqueous solution . Similar carboxyamine‐based tridentate N , N , O ligands which easily coordinate to copper(II), cobalt(II) and nickel(II) ions to form one dimensional coordination polymers have been reported in the literature .…”

Metal-coordination synthesis of a natural injectable photoactive hydrogel with antibacterial and blood-aggregating functions for cancer thermotherapy and mild-heating wound repair

“…1b). [57][58][59][60][61] The BiH and allantoin (Alla) were co-loaded into the hydrogel to render combined photothermal cancer therapy and regenerative property to the hydrogel. Alla is a pharmaceutically active agent that can promote wound healing by regulating inflammatory reactions, stimulating fibroblast proliferation, and inducing extracellular matrix formation.…”