Drainage basin-scale morphometric analysis and morphological evidence of tectonics represent helpful tools to evaluate and investigate morphoneotectonic processes in tectonically active regions. In this perspective, we applied an integrated analysis to the Abruzzo Periadriatic Area, between the Tronto and Sinello rivers (Central Italy). It involved morphometric analysis, structural geomorphological field mapping, and detailed analysis of fluvial terraces. Geomorphic indexes and markers (e.g., Irta, SL index, ksn, and knickpoints) were used in this study to detect the response of landscapes to drainage systems’ unsteadiness and tectonic deformation processes, possibly induced by the ongoing activity of the buried tectonic structures. Furthermore, the investigation of morphological field evidence of tectonics, integrated with the analysis of fluvial terraces’ spatial and temporal arrangement, was performed to assign relative, geomorphologically-based, age constraints of the landscape evolution. The resulting data allowed us to define domains affected by different morphostructural and morphoneotectonic processes, related to the impact and ongoing activity of the five detected families of structural elements (S1, F1, F2, F3, and F4), mainly characterized by compressive, extensional, and transtensive kinematics. Finally, this study could represent a scientific basis for integrating morphometric, fluvial, and tectonic geomorphology analysis to better define the main phases of the landscape evolution and the impact of morphoneotectonic processes on fluvial environments in uplifting piedmont areas.